Evidence map›Paper›PMID 41903505›Full record

ArticleVaccine2026

Evaluation of Rift Valley fever vaccine candidates in pregnant rodent models.

Cigdem Alkan, Eduardo Jurado-Cobena, Tetsuro Ikegami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cigdem AlkanDepartment of Pathology, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA.
Eduardo Jurado-CobenaDepartment of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA.
Tetsuro IkegamiDepartment of Pathology, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA; The Sealy Institute for Vaccine Sciences, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA; The Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA. Electronic address: teikegam@utmb.edu.

Funding

EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SOONG, LYNN · 1997 to 2025
$3.1M
Safety and immunogenicity of a novel Rift Valley fever candidate vaccine, RVax-1R01AI150917 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI IKEGAMI, TETSURO · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI150917NIAID NIH HHS T32 AI007526
6 · The paper itself

Abstract

backgroundRift Valley fever virus (RVFV) causes significant disease in humans and livestock. Immunogenicity of candidate vaccines rMP-12 and RVax-1 show promise, but their placental tropism and potential effects on fetal outcomes remain incompletely understood, particularly across different animal models. Understanding species-specific placental replication is essential to optimize vaccine safety in pregnant populations.

objectiveTo evaluate the placental tropism and fetal outcomes of RVFV candidate vaccines rMP-12 and RVax-1 in pregnant Sprague-Dawley (SD) rats and C57BL/6 mice.

methodsPregnant SD rats and C57BL/6 mice were vaccinated intramuscularly at embryonic day 14 (E14) with 1 × 10

resultsIn rats, both vaccines showed minimal replication in placental and fetal tissues, indicating limited vertical transmission. In contrast, mice were more susceptible: viral RNA and antigens were detected in maternal livers, placentas, and fetal compartments. rMP-12-vaccinated mice showed reduced litter sizes and autolyzed placental tissues, whereas RVax-1-vaccinated mice exhibited fetal demise, with viral antigens detected in spongiotrophoblasts, syncytiotrophoblasts, and trophoblast giant cells of the junctional and labyrinth zones.

conclusionsRVFV vaccines rMP-12 and RVax-1 exhibit residual placental tropism in mice but minimal replication in rats, highlighting species-specific differences. Mouse models may be useful for studying placental tropism, and these findings inform future optimization of vaccine safety during pregnancy.

Indexed as

Rift Valley FeverRift Valley fever virusViral VaccinesAnimalsAntibodies, ViralDisease Models, AnimalFemaleInfectious Disease Transmission, VerticalMiceMice, Inbred C57BLPlacentaPregnancyRatsRats, Sprague-DawleyVirus ReplicationAntibodies, ViralViral VaccinesLive-attenuated vaccineMouse modelMP-12 vaccinePlacentaPregnancyRat modelReverse geneticsRift Valley fever virusRVax-1 vaccine

Identifiers

PMID41903505
PMCPMC13035337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.