Evidence map›Paper›PMID 41903432›Full record

ReviewCurrent opinion in neurobiology2026

Addressing degeneracy in rodent studies of cognition.

Christine M Constantinople

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christine M ConstantinopleCenter for Neural Science, New York University, New York, NY, 10003, USA. Electronic address: constantinople@nyu.edu.

Funding

Acetylcholine determines dopamine's role in learning versus movingR01MH136272 · NIMH · NEW YORK UNIVERSITY · PI Christine M Constantinople · 2024 to 2026
$1.8M
CRCNS: Multiregional computations for value-based decision-makingR01DA065418 · NIDA · NEW YORK UNIVERSITY · PI Christine M Constantinople, Cristina Savin · 2025 to 2026
$781k
NIDA NIH HHS R01 DA065418NIMH NIH HHS R01 MH136272
6 · The paper itself

Abstract

In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that actually use those computations, as opposed to simpler heuristics. Here, I describe the problem of adjudicating between degenerate behavioral algorithms and degenerate neural implementations in perceptual and value-based decision-making tasks. Multi-dimensional behavioral measures allow researchers to build arguments from numerous lines of evidence in favor of or against hypotheses about algorithmic strategies. Neural perturbations and individual differences can help resolve degenerate neural implementations. Rigorously contending with these issues is critical for leveraging rodent models to reveal mechanisms of cognition.

Indexed as

BrainCognitionDecision MakingModels, NeurologicalAlgorithmsAnimalsRodentia

Identifiers

PMID41903432
PMCPMC13089310

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.