Evidence map›Paper›PMID 41903358›Full record

ArticleCarbohydrate research2026

Ring opening, conformational analysis and NagZ inhibition of a GlcNAc-configured iminosugar-derived aziridine.

Nicolas Auberger, Amr M El-Araby, Thanh Van Tran, Rhona Feltzer, Ana Poveda, Jesús Jiménez-Barbero, Shahriar Mobashery, Yves Blériot

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas AubergerUniversité de Poitiers, UMR-CNRS 7285, IC2MP, Poitiers, 86073, France. Electronic address: nicolas.auberger@univ-poitiers.fr.
Amr M El-ArabyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Thanh Van TranUniversité de Poitiers, UMR-CNRS 7285, IC2MP, Poitiers, 86073, France.
Rhona FeltzerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Ana PovedaCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160, Derio, Spain.
Jesús Jiménez-BarberoCICbioGUNE, Basque Research and Technology Alliance, Parque Científico Tecnológico de Bizkaia Building 801A, E-48160, Derio, Spain; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, E-48009, Bilbao, Spain; Department of Inorganic & Organic Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, E-48940, Leioa, Spain; Centro de Investigación Biomedica En Red de Enfermedades Respiratorias, C/ Monforte de Lemos, 3-5. Pabellón 11, Planta 0, Fuencarral-El Pardo, E-28029, Madrid, Spain. Electronic address: jjbarbero@cicbiogune.es.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA. Electronic address: mobashery@nd.edu.
Yves BlériotUniversité de Poitiers, UMR-CNRS 7285, IC2MP, Poitiers, 86073, France. Electronic address: yves.bleriot@univ-poitiers.fr.

Funding

Targeting Gram-Negative Bacteria for Antibacterial StrategiesR35GM158092 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Shahriar Mobashery · 2025 to 2026
$829k
NIGMS NIH HHS R35 GM158092
6 · The paper itself

Abstract

The synthesis of 1,N-anhydro-2-acetamido-2-deoxy-α-homonojirimycin (1,N-anhydro-α-HNJNAc) from 3,4,6-tri-O-benzyl-N-acetyl-d-glucosamine is disclosed. Its conformational analysis by NMR indicated a

Indexed as

AcetylglucosamineAziridinesEnzyme InhibitorsImino SugarsCarbohydrate ConformationAcetylglucosamineaziridineAziridinesEnzyme InhibitorsImino SugarsAziridine ring openingIminosugar-C-GlycosideInhibitionNagZ

Identifiers

PMID41903358
PMCPMC13284764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.