Evidence map›Paper›PMID 41903318›Full record

ArticleRedox biology2026

Genetically engineered Escherichia coli Nissle 1917 enabling on-site melanin synthesis attenuates radiation enteritis through ferroptosis inhibition and gut microbiota modulation.

Chaoqun Lv, Hongqing Li, Xiang Li, Wen Shi, Wenbo Li, Zhenxing Li, Xinyue Hu, Xinxin Liu, Yuanyuan Ai, Zhipeng Wen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chaoqun LvDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Hongqing LiDepartment of Nuclear Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China; Department of Anesthesiology, Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Xiang LiDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Wen ShiDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Wenbo LiDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Zhenxing LiDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Xinyue HuDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Xinxin LiuDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Yuanyuan AiDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Zhipeng WenDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Feng LiuDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Yi RuDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Haijun XiaoDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Jingchao LiDepartment of Nuclear Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China. Electronic address: lijc@tmmu.edu.cn.
Xiao ChenDepartment of Nuclear Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China. Electronic address: xiaochen229@tmmu.edu.cn.
Kaijun LiuDepartment of Intensive Care Medicine, Army Medical Center of PLA, Daping Hospital, Army Medical University, No.10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China. Electronic address: kliu@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation enteritis (RE) poses a clinically-relevant therapeutic challenge with limited effective interventions. Engineered probiotic drug delivery systems offer innovative strategies for precise treatment of inflammatory disease. However, both the practical efficacy and therapeutic mechanism of engineered probiotic agents for RE alleviation remains largely unclear. Herein, the melanin with natural radioprotective function was applied to modify engineered Escherichia coli Nissle 1917 that contains the tyrosinase gene (EcN-Tyr), which were further formulated into orally administrable microspheres (EcN-Tyr (A/C)

Indexed as

EnteritisEscherichia coliFerroptosisGastrointestinal MicrobiomeMelaninsRadiation InjuriesAnimalsGenetic EngineeringHumansMiceProbioticsMelaninsEcN-Tyr(A/C)(1) microspheresFerroptosisgut microbiotaMelaninRadiation enteritis

Identifiers

PMID41903318
PMCPMC13054290

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.