Evidence map›Paper›PMID 41903204›Full record

ArticleJournal of experimental botany2026

Culmorin inhibits detoxification of the mycotoxin deoxynivalenol by plant UDP-glucosyltransferases.

Herbert Michlmayr, Gerlinde Wiesenberger, Katrin Rehak, Marta Sopel, Kristina Funtak, Alexandra Malachová, Philipp Fruhmann, Julia Weber, Marie Dufresne, Rudolf Krska and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental botany, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Herbert MichlmayrDepartment of Agricultural Sciences, BOKU University, Institute of Microbial Genetics, Tulln 3430, Austria.ORCID 0000-0001-7998-1494
Gerlinde WiesenbergerDepartment of Agricultural Sciences, BOKU University, Institute of Microbial Genetics, Tulln 3430, Austria.ORCID 0000-0002-3788-7974
Katrin RehakDepartment of Agricultural Sciences, BOKU University, Institute of Microbial Genetics, Tulln 3430, Austria.
Marta SopelDepartment of Agricultural Sciences, BOKU University, Institute of Bioanalytics and Agro-Metabolomics, Tulln 3430, Austria.
Kristina FuntakDepartment of Agricultural Sciences, BOKU University, Institute of Microbial Genetics, Tulln 3430, Austria.
Alexandra MalachováDepartment of Agricultural Sciences, BOKU University, Institute of Bioanalytics and Agro-Metabolomics, Tulln 3430, Austria.
Philipp FruhmannInstitute of Applied Synthetic Chemistry, TU Wien, Vienna 1060, Austria.ORCID 0000-0001-9165-5202
Julia WeberInstitute of Applied Synthetic Chemistry, TU Wien, Vienna 1060, Austria.
Marie DufresneUniversité Paris-Saclay, INRAE, UR BIOGER, Palaiseau 91120, France.ORCID 0000-0001-6575-6472
Rudolf KrskaDepartment of Agricultural Sciences, BOKU University, Institute of Bioanalytics and Agro-Metabolomics, Tulln 3430, Austria.ORCID 0000-0001-6843-9755
Franz BerthillerDepartment of Agricultural Sciences, BOKU University, Institute of Bioanalytics and Agro-Metabolomics, Tulln 3430, Austria.ORCID 0000-0001-5883-2879
Gerhard AdamDepartment of Agricultural Sciences, BOKU University, Institute of Microbial Genetics, Tulln 3430, Austria.ORCID 0000-0002-3008-3797

Funding

Austrian Science Fund
6 · The paper itself

Abstract

The Fusarium metabolite culmorin (CUL) frequently co-occurs with the mycotoxin deoxynivalenol (DON) on cereals. While DON is recognized as a major Fusarium virulence factor on plants, the function of CUL is still unclear. In this study, we show that CUL-deficient F. graminearum mutants created by deletion of the terpene synthase gene CLM1 are less aggressive on wheat than the wild-type, and this is accompanied by increased DON-3-glucoside/DON ratios in infected wheat ears. In root elongation assays with wheat and Brachypodium distachyon, CUL had no effect alone but significantly increased the toxicity of DON. Analysis of roots treated with DON and/or CUL further indicated that both wheat and B. distachyon are able to glucosylate CUL and that its presence impedes DON-glucosylation in both species. We identified two B. distachyon UDP-glucosyltransferases (UGTs) able to glucosylate CUL, and further investigated the effects of CUL on the kinetics of validated DON-glucosylating plant UGTs (BdUGT5g03300, HvUGT13248, OsUGT79). This suggested that CUL inhibits DON-glucosylation either by serving as a competitive substrate with DON or by unproductive binding. BdUGT5g03300 in particular was strongly inhibited by CUL and even its glucosides. Our results indicate that CUL contributes to Fusarium virulence by weakening plant defences related to UGT-catalysed DON-detoxification. As even CUL-glucosides are potentially inhibitory to UGTs, this implies a complex synergy of CUL with DON.

Indexed as

BrachypodiumFusariumGlucosyltransferasesMycotoxinsPlant ProteinsTrichothecenesTriticumSesquiterpenesculmorindeoxynivalenolGlucosyltransferasesMycotoxinsPlant ProteinsSesquiterpenesTrichothecenesCulmorindeoxynivalenolFusariumglucosylationinhibition kineticsmycotoxinplant–pathogen interactionrootsecondary metabolismsesquiterpenetrichothecenevirulencewheat

Identifiers

PMID41903204
PMCPMC13415951

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.