ArticleJournal of magnetic resonance imaging : JMRI2026
A MR Fingerprinting Development Kit for Quantitative 3D Brain Imaging.
Rasim Boyacioglu, Thomas Kluge, Guido Buonincontri, Wei-Ching Lo, Stephan Kannengiesser, Mathias Nittka, Arashdeep Kaur, Andrew Dupuis, Dan Ma, Chaitra Badve and 2 more
Abstract read
In one paragraphArticle in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Rasim BoyaciogluDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3099-2640 Thomas KlugeResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
Guido BuonincontriResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.ORCID 0000-0002-8386-639X Wei-Ching LoSiemens Medical Solutions, Boston, Massachusetts, USA.
Stephan KannengiesserResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
Mathias NittkaResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
Arashdeep KaurDepartment of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Andrew DupuisDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
Dan MaDepartment of Neurosurgery, Duke University, Durham, North Carolina, USA.
Chaitra BadveDepartment of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.ORCID 0000-0001-8547-8019 Mark A GriswoldDepartment of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Yong ChenDepartment of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.ORCID 0000-0001-6183-2693 Funding
Development of fast diffusion magnetic resonance fingerprinting of the prostate to avoid unnecessary biopsiesR01CA292091 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Yong Chen, Leonardo Kayat Bittencourt · 2024 to 2026
$3.2MDevelopment of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast CancerR01CA282516 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Yong Chen, Dan Ma · 2023 to 2026
$2.4MDevelopment of Magnetic Resonance Fingerprinting in Kidney for Evaluation of Renal Cell CarcinomaR01CA266702 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, YONG, TIRUMANI, SREE HARSHA · 2022 to 2025
$2.0MOptimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud-Based ReconstructionR01NS134849 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yong Chen, Pew-Thian Yap · 2024 to 2026
$1.9MNCI NIH HHS R01 CA266702NCI NIH HHS R01 CA282516NCI NIH HHS R01 CA292091NIH HHS R01CA266702NIH HHS R01CA282516NIH HHS R01CA292091NIH HHS R01NS134849NINDS NIH HHS R01 NS134849Siemens Healthineers
6 · The paper itselfAbstract
backgroundMagnetic resonance fingerprinting (MRF) is an emerging quantitative imaging technique that enables multiparametric tissue characterization, but its adoption has been hindered by the complexity of data acquisition and post-processing. These technical and implementation challenges have limited its broader clinical deployment. PURPOSE: To develop a modular MRF Development Kit (MRFDK) that enables efficient sequence design, streamlined implementation, and real-time image reconstruction. STUDY TYPE: Prospective. POPULATION: T FIELD STRENGTH/SEQUENCE: 3 T, MR Fingerprinting. ASSESSMENT: Accuracy of T STATISTICAL TESTS: t-test, in vivo repeatability was calculated with Bland-Altman analysis on healthy volunteer scan-rescan data, significance level p < 0.01.
resultsPhantom results showed high accuracy in T DATA
conclusionA modular MRF development package enabling efficient 3D acquisition and rapid inline reconstruction was developed and evaluated in this study. LEVEL OF EVIDENCE: 1: TECHNICAL EFFICACY: Stage 2.
Indexed as
BrainBrain NeoplasmsImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingAdultAlgorithmsFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingProspective StudiesReproducibility of ResultsaccuracyBland–Altmanclinical translationmappingmetastasisMRFquantitative MRIrelaxationrepeatability
Identifiers
PMID41903184
PMCPMC13122508
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