← GIP/GLP-1 & amylin agonists × kidney outcomes

TrialJAMA cardiology2026

Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial.

Steven E Nissen et al.PubMed ↗Full text ↗Publisher ↗

A secondary analysis of NCT04255433. The report of the trial’s main result is not on the map, and the numbers here are shown and do not vote.

What the trial testedas reported · 13,165 people · 2026

Not counted

Lowered kidney outcomes

−16%−21% to −10%

24 in 100 instead of 27

Bigger than 4 in 10 on the map

As reported

HR 0.84, 95% CI 0.79–0.90

One number in the abstract

the abstract, start to end

… patients (27.4%; hazard ratio [HR], 0.84; 95% CI, 0.79-0.90; P < .001).

← favours treatmentfavours comparator →
could be chance
Kidney outcomes
HR 0.840.79–0.90
GLP-1 receptor agonistsGIP/GLP-1 & amylin agonistsKidney outcomes
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4 papers cite it

2026
this papercites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 41903177