Evidence map›Paper›PMID 41903158›Full record

ArticleCardiovascular therapeutics2026

IL6/IL10/TLR4 Govern Immunogenic Cell Death in Aortic Dissection.

Yukui Du, Dongqing Chang, Bofeng Yu, Li Zhang, Liang He, Fengxia Wang, Shaoyan Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yukui DuDepartment of Cardiac Surgery, Center for Cardiac and Panvascular Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0001-7243-2377
Dongqing ChangDepartment of Cardiac Surgery, Center for Cardiac and Panvascular Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0008-7732-5715
Bofeng YuDepartment of Cardiac Surgery, Center for Cardiac and Panvascular Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0000-4116-2709
Li ZhangDepartment of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0003-3915-7988
Liang HeDepartment of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0005-1618-9076
Fengxia WangCardiovascular Medicine Department, Center for Cardiac and Panvascular Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.ORCID https://orcid.org/0009-0000-9043-8062
Shaoyan ChangCapital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China, shouer.com.cn.ORCID https://orcid.org/0000-0002-1088-6330

Funding

Department of Human Resources and Social Security of Xinjiang Uygur Autonomous RegionNational Natural Science Foundation of China 82001555/0417Xinjiang Uygur Autonomous Region Natural Science Fund 2024D01C107
6 · The paper itself

Abstract

backgroundAortic dissection (AD), a life-threatening cardiovascular emergency, poses a significant threat to global cardiovascular health. Emerging evidence implicates programmed cell death (PCD) as a critical driver of AD pathogenesis, yet the molecular mechanisms remain poorly defined. This study systematically investigates PCD-related biomarkers in AD to identify novel therapeutic targets.

methodsMultiomics analysis integrated transcriptome sequencing data from eight AD and five control aortic tissues. Differentially expressed genes (DEmRNAs, n = 3094) were intersected with 1574 programmed cell death-related genes (PCD-RGs) to identify candidate biomarkers. Protein-protein interaction (PPI) networks, functional enrichment, immune infiltration profiling, and drug-target prediction were employed to characterize key molecular drivers.

resultsThree PCD-associated biomarkers were identified: IL6 (11.8-fold upregulated), IL10 (26.1-fold upregulated), and TLR4 (0.38-fold downregulated). These biomarkers exhibited significant enrichment in immunoregulatory pathways including "MYC Targets V1" (FDR < 0.05), with IL10 showing strong immune microenvironment correlations (memory B cells: r = 0.62; endothelial cells: r = -0.58). Regulatory network analysis revealed 58 transcription factors (STAT1/SP1/IRF8) and six key miRNAs (e.g., miR-204-5p) orchestrating biomarker expression. Drug-target mapping identified 91 repurposable agents, including etanercept-szzs (dual IL6/IL10 inhibitor) and TLR4-modulating compounds.

conclusionThis study establishes IL6, IL10, and TLR4 as central regulators of PCD-mediated AD pathogenesis, implicating immune-vascular crosstalk and immunogenic cell death as therapeutic entry points. The identified biomarker network and drug candidates provide a translational framework for developing precision therapies against AD.

Indexed as

AortaAortic AneurysmAortic DissectionApoptosisInterleukin-10Interleukin-6Toll-Like Receptor 4Apoptosis Regulatory ProteinsDissection, Thoracic AortaGene Expression ProfilingGene Regulatory NetworksHumansMicroRNAsProtein Interaction MapsSignal TransductionTranscriptomeApoptosis Regulatory ProteinsIL6 protein, humanInterleukin-10Interleukin-6MicroRNAsTLR4 protein, humanToll-Like Receptor 4aortic dissectionbiomarkersimmune infiltrationprogrammed cell deathregulatory networkstherapeutic targetstranscriptome sequencing

Identifiers

PMID41903158
PMCPMC13140880

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.