Evidence map›Paper›PMID 41903131›Full record

ArticleCirculation2026

Multimodality Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women and Men.

Harmony R Reynolds, Akiko Maehara, Bobby Heydari, Nathaniel R Smilowitz, Tara Sedlak, Yader Sandoval, Hayder D Hashim, Kevin R Bainey, Akl C Fahed, Natalia Pinilla Echeverri and 18 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02905357 (Heart Attack Research Program- Imaging Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02905357 active not recruitingnot on this map

Heart Attack Research Program- Imaging Study

TypeobservationalSponsorNYU Langone HealthRan2016 to 2027Enrolled450ConditionsMyocardial InfarctionArmsOCT, CMR
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Harmony R ReynoldsDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0000-0003-0284-0655
Akiko MaeharaTakagi Hospital, Fukuoka, Japan (A.M.).ORCID 0000-0002-1910-8447
Bobby HeydariDepartments of Medicine and Radiology, Brigham and Women's Hospital, Boston, MA (B.H.).
Nathaniel R SmilowitzDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0000-0002-6823-2815
Tara SedlakVancouver General Hospital, Vancouver, BC, Canada (T.S., J.S.).
Yader SandovalMinneapolis Heart Institute, Minneapolis, MN (Y.S.).ORCID 0000-0003-4800-2972
Hayder D HashimSection of Interventional Cardiology, Medstar Washington Hospital Center, Washington, D.C. (H.D.H.).ORCID 0000-0003-2194-5428
Kevin R BaineyMazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada (K.R.B.).ORCID 0000-0002-5458-4617
Akl C FahedCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (A.C.F.).ORCID 0000-0002-4849-6389
Natalia Pinilla EcheverriDepartment of Medicine, McMaster University, Hamilton, ON, Canada (N.P.E.).ORCID 0000-0001-7784-0348
Mitsuaki MatsumuraCardiovascular Research Foundation, New York, NY (A.M., M.M.).ORCID 0000-0002-2082-0247
Mobeen AhmedDepartment of Medical Imaging, Western University, London, ON, Canada (M.A.).ORCID 0000-0002-2075-0349
Jacqueline SawVancouver General Hospital, Vancouver, BC, Canada (T.S., J.S.).ORCID 0000-0002-7027-984X
Aun-Yeong ChongUniversity Of Ottawa Heart Institute, Ottawa, ON, Canada (A.-Y.C.).ORCID 0000-0001-8172-5318
Atul SharmaDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.
Anais HausvaterDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.
Yuhe XiaDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0000-0001-5723-7648
Jennifer A TremmelDepartment of Medicine, Stanford University School of Medicine, Stanford, CA (J.A.T.).ORCID 0000-0001-6620-9139
Shuangbo LiuDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada (S.L.).ORCID 0000-0002-8722-0182
Puja K MehtaEmory Women's Heart Center and Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University School of Medicine, Atlanta, GA (P.K.M.).ORCID 0000-0002-5678-812X
Bryan HarFoothills Medical Center, University of Calgary, Calgary, AB, Canada (B.H.).ORCID 0000-0003-2760-8967
Sripal BangaloreDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0000-0001-9485-0652
Michael AttubatoDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.
Lori Vales LayDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.
Alair HoldenDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0009-0003-8804-0161
Chang YuDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.
Judith S HochmanDepartments of Medicine (H.R.R., N.R.S., A.S., A. Hausvater, Y.X., S.B., M.A., L.V.L., A. Holden, C.Y., J.S.H.), NYU Grossman School of Medicine, New York, NY.ORCID 0000-0002-5889-5981
HARP Research Group

Funding

American Heart Association-American Stroke Association 16SFRN28730004American Heart Association-American Stroke Association 812162
6 · The paper itself

Abstract

backgroundMyocardial infarction with nonobstructive coronary arteries (MINOCA) has several underlying causes, including mimicking conditions in some cases. Imaging is recommended to identify MINOCA etiologies, but it remains unclear which patients are most likely to have abnormal findings. We characterized MINOCA mechanisms, analyzed predictors of imaging abnormalities, and explored sex differences.

methodsWe enrolled patients with clinical diagnosis of myocardial infarction in an international, prospective, diagnostic study at 28 sites in the United States, Canada and United Kingdom. After a women-only phase, we included both sexes. Individuals with ≥50% diameter stenosis or coronary dissection on angiography, or alternate causes for the clinical presentation, were excluded. Participants had multivessel coronary optical coherence tomography (OCT) during index coronary angiography and cardiac magnetic resonance imaging (CMR) within 1 week. Independent core laboratories interpreted imaging, blinded to other results.

resultsAmong 754 patients enrolled, 389 had MINOCA, and 336 with MINOCA underwent OCT (270 women and 66 men); CMR was completed in 284 (85%). An OCT-defined culprit lesion was identified in 45% (116 of 270 women [43%] and 35 of 66 men [53%],

conclusionsThe combination of multivessel coronary OCT and CMR in patients with a clinical diagnosis of MINOCA confirmed myocardial infarction in 59% and identified an alternate cause (MINOCA mimic) in 20%. Clinical factors had limited usefulness to predict imaging abnormalities. No sex differences in imaging results were detected. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02905357.

Indexed as

Coronary VesselsMINOCAMultimodal ImagingMyocardial InfarctionTomography, Optical CoherenceAgedCoronary AngiographyFemaleHumansMaleMiddle AgedProspective StudiesSex Factorscoronary circulationmagnetic resonance imagingMINOCAmyocardial infarctionOCTsextomography, optical coherence

Identifiers

PMID41903131
PMCPMC13322285

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.