Evidence map›Paper›PMID 41902999›Full record

Observational studyJapanese journal of ophthalmology2026

Longitudinal evaluation of peripheral photoreceptor atrophy in fundus albipunctatus.

Takuhiro Hayakawa, Kei Mizobuchi, Takaaki Hayashi, Taro Kominami, Koji M Nishiguchi, Shinji Ueno, Kazuki Kuniyoshi, Mineo Kondo, Takeshi Iwata, Kaoru Fujinami and 1 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takuhiro HayakawaDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
Kei MizobuchiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Taro KominamiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Koji M NishiguchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Shinji UenoDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Kazuki KuniyoshiDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osaka-sayama, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Mie, Japan.
Takeshi IwataDivision of Molecular and Cellular Biology, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Kaoru FujinamiDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
Kazushige TsunodaDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan. kazushige.tsunoda@kankakuki.jp.

Funding

Grant by National Hospital Organization for young investigators R4-NHO-PI-03Grants from the Japan Society for the Promotion of Science 2 1 K 0 9 7 1 2Grants from the Japan Society for the Promotion of Science JSPSNational Hospital Organization Network Research Fund H30-NHO-Sensory Organs-03Research Committee on the Epidemiology of Intractable Diseases of Retinochoroidal and Optic Nerve Atrophy from Ministry of Health, Labour and Welfare of Japan 23FC1043Wellcome Trust FC001043
6 · The paper itself

Abstract

purposeTo investigate the long-term longitudinal changes of the retinal morphology and visual function in patients with fundus albipunctatus (FA). STUDY

designRetrospective observational study.

methodsSeventeen Japanese patients with FA who had pathogenic variants of the RDH5 gene were studied in a multicenter retrospective study.

resultsThe baseline ages ranged from 3 to 61 years, and the patients were followed longitudinally for 3 to 21 years. The relative size of the flecks/dots decreased throughout the course of the disease; rapidly in the first and second decades of life and slowly thereafter. The flecks/dots in the OCT images were seen as hyperreflective flat deposits on the retinal pigment epithelium in the first decade of life, and as hyperreflective pile-like formations that extended to the ellipsoid zone (EZ) of the photoreceptors after the second decade of life. At later ages, the EZ in the mid-peripheral retina was not present due to photoreceptor atrophy. The Goldmann visual fields had a peripheral constriction in 7 of 11 cases that developed during the course of the disease process.

conclusionThe long-term longitudinal observations of the morphological changes of the retina and visual fields revealed that FA is a slowly progressive retinal dystrophy with atrophy of the peripheral photoreceptors in older patients. These findings will be very important information for the patients when providing genetic counseling.

Indexed as

Night BlindnessPhotoreceptor Cells, VertebrateTomography, Optical CoherenceVisual AcuityVisual FieldsAdolescentAdultAlcohol OxidoreductasesAtrophyChildChild, PreschoolElectroretinographyFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiAlcohol Oxidoreductasesretinol dehydrogenase 5Dots/flecksFundus albipunctatusLongitudinal observationOCTRDH5

Identifiers

PMID41902999
PMCPMC13452752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.