ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Nodule size significantly affects the diagnostic value of chinese thyroid imaging reporting and data system: a multi-center retrospective study.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to investigate the influence of thyroid nodule size on the diagnostic efficacy of the Chinese thyroid imaging reporting and data system (C-TIRADS). PATIENTS AND
methodsThis retrospective study included pathologically confirmed thyroid nodules categorized into ≤ 10 mm and > 10 mm groups. The ultrasound characteristics of these nodules were evaluated, and C-TIRADS scoring and classification were performed. Receiver operating characteristic (ROC) curves were generated to ascertain optimal threshold values for scoring and classification in both groups. Subsequently, the diagnostic accuracies of C-TIRADS for thyroid nodules in the two groups were compared.
resultsThe ≤ 10 mm group included 237 benign, 1 low-risk, and 1,376 malignant nodules. The > 10 mm group included 499 benign, 13 low-risk, and 349 malignant nodules. The Mann-Whitney U test results revealed that scores for malignant thyroid nodules were significantly ˃ those for benign nodules in both groups. The ROC curves (AUC) for C-TIRADS scoring and classification in the ≤ 10 mm group were 0.707 and 0.684, respectively, with optimal threshold values of > 2 points and > C-TR 4B. In the > 10 mm group, AUCs for C-TIRADS scoring and classification were 0.927 and 0.922, respectively, with optimal threshold values of > 1 point and > C-TR of 4A. The > 10 mm group had greater specificity, negative predictive value (NPV) and accuracy than the ≤ 10 mm group, whereas the > 10 mm group had lower positive predictive value (PPV) than the ≤ 10 mm group at these optimal thresholds (all P-values < 0.001).
conclusionThe diagnostic performance of C-TIRADS scoring and classification was significantly lower for thyroid nodules with a diameter of ≤ 10 mm than for those with a diameter of > 10 mm.
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