Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Real-world management and outcomes of immune-mediated diarrhea and colitis: gaps in guideline adherence and opportunities for implementation.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From toxicity to signal: positioning symptom clusters as pharmacodynamic indicators in ICI therapy.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeImmune-mediated diarrhea and colitis (IMDC) is a high-risk toxicity frequently experienced by patients treated with immune checkpoint inhibitors (ICIs) and requiring rapid supportive care interventions. Delays in IMDC reporting and inconsistent guideline adherence increase symptom burden and emergency department (ED) utilization. Although current practice guidelines provide IMDC management recommendations, adherence in routine oncology care remains uncertain. This study evaluated management and guideline concordance for clinically significant IMDC at a single National Cancer Institute-designated comprehensive cancer center to identify workflow opportunities to improve supportive management.
methodsWe conducted a retrospective observational study of adults treated with ICIs between 2011 and 2024 who developed IMDC requiring systemic immunosuppression. Electronic health record (EHR) data were used to characterize patient demographics, IMDC reporting patterns, and to assess National Comprehensive Cancer Network (NCCN) guideline concordance in terms of IMDC diagnostic workup and management across care settings.
resultsED clinicians demonstrated greater adherence to NCCN guidelines than outpatient oncology providers. Of the 17 patients with IMDC, nine (52.94%) required ED management, with an average immunosuppressive therapy duration of 92.29 days, and only four (23.53%) resumed ICI therapy following IMDC resolution. Despite 88.24% of patients presenting with moderate-severe IMDC, 41.18% experienced symptoms for over a week before seeking medical care. Over 40% of patients with IMDC experienced concurrent immune-related adverse events (irAEs), with dermatitis and hepatitis being the most common.
conclusionOur findings reveal actionable targets for improving supportive management of clinically significant IMDC. Implementing standardized workflows and decision-support tools may strengthen evidence-based IMDC care, reduce treatment delays, and improve patient outcomes.
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Registered trials
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