Evidence map›Paper›PMID 41902905›Full record

GuidelineJournal of gastroenterology2026

Guidelines for the management of Helicobacter pylori infection in Japan: 2024 revised edition.

Hajime Isomoto, Tadashi Shimoyama, Masanori Ito, Takako Osaki, Osamu Toyoshima, Juntaro Matsuzaki, Hiroyoshi Ota, Daisuke Chinda, Mitsushige Sugimoto, Soichiro Sue and 19 more

Abstract readPractice Guideline
In one paragraph

Guideline in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Antimicrobial Resistance-Stratified Efficacy of Vonoprazan, Clarithromycin, and Metronidazole Therapy forJGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  5. Review
  6. AdolescentChildren (Basel, Switzerland) · 2026
    Review
  7. Review
  8. From screening to surveillance: integrated prevention ofThe Lancet regional health. Western Pacific · 2026
    Review
  9. Antibiotics (Basel, Switzerland) · 2026
    Review
  10. Potassium-competitive acid blockers forFrontiers in cellular and infection microbiology · 2026
    Review
  11. Differences and trends in worldwide clinical guidelines forTranslational gastroenterology and hepatology · 2026
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Hajime Isomoto *Department of Gastroenterology and Nephrology, Tottori University School of Medicine, Yonago, Japan.ORCID 0000-0001-8858-6525
Tadashi Shimoyama *Aomori General Health Examination Center, Aomori, Japan.ORCID 0000-0001-9615-0000
Masanori ItoDepartment of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Takako OsakiDepartment of Infectious Diseases, Kyorin University School of Medicine, Mitaka, Japan.ORCID 0000-0002-6430-4666
Osamu ToyoshimaGastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.ORCID 0000-0002-6953-6079
Juntaro MatsuzakiKeio University Faculty of Pharmacy, Tokyo, Japan.
Hiroyoshi OtaDepartment of Clinical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan.
Daisuke ChindaDivision of Endoscopy, Hirosaki University Hospital, Hirosaki, Japan.ORCID 0000-0003-1690-5923
Mitsushige SugimotoDivision of Genome-Wide Infectious Microbiology, Research Center for GLOBAL and LOCAL Infectious Disease, Oita University, Yufu, Japan.ORCID 0000-0002-9194-7392
Soichiro SueDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0002-4645-1291
Koji OtaniDepartment of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0001-9075-6415
Toshihiro NishishizawaDepartment of Gastroenterology and Hepatology, International University of Health and Welfare Narita Hospital, Narita, Japan.ORCID 0000-0003-4876-3384
Osamu HandaDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, Kurashiki, Japan.ORCID 0000-0003-2228-0405
Takahisa FurutaFuruta Clinic for Internal Medicine, Iwata, Japan.ORCID 0000-0002-2202-595X
Hideki MoriDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0001-8830-4671
Masumi OkudaDepartment of Pediatrics, Hyogo Medical University, Nishinomiya, Japan.ORCID 0000-0001-5263-2868
Yuichiro IkebuchiDepartment of Gastroenterology and Nephrology, Tottori University School of Medicine, Yonago, Japan.
Kazuhiko InoueJunpukai Health Maintenance Center, Okayama, Japan.
Kyoko SakaiDepartment of Laboratory Medicine, Suita Saiseikai Hospital, Suita, Japan.
Yuji NadataniDepartment of Advanced Preventive Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0001-7081-8746
Ryota NiikuraPreventive Medicine Center, Tokyo Medical University, Tokyo, Japan.ORCID 0000-0001-5047-6195
Kazuo YashimaDepartment of Gastroenterology and Nephrology, Tottori University School of Medicine, Yonago, Japan.ORCID 0000-0002-1180-0789
Tamaki IkuseDepartment of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-5493-6504
Toshihiko KakiuchiDepartment of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan.ORCID 0000-0002-9995-5522
Momoko TsudaDepartment of Gastroenterology, Sapporo Cancer Screening Center, Public Interest Foundation Hokkaido Cancer Society, Sapporo, Japan.ORCID 0000-0002-2396-8036
Katsuhiro MabeMabe Goryokaku Gastrointestinal Endoscopy Clinic, Hakodate, Japan.
Yasuhiro MizunoMa-Ru Clinic Yokosuka, Yokosuka, Japan.
Kazunari MurakamiDepartment of Gastroenterology, Oita University School of Medicine, Yufu, Japan.ORCID 0000-0003-2668-5039
Hidekazu SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, 259-1193, Japan. hsuzuki@tokai.ac.jp.ORCID 0000-0002-8994-6163

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Japanese Society for Helicobacter Research (JSHR) published the fifth edition of the guidelines for the management of Helicobacter pylori (H. pylori) infection in 2024 in Japanese language.

methodsThis edition of JSHR guidelines was first developed in accordance with the Minds Clinical Practice Guideline and Grading of Recommendations Assessment, Development, and Evaluation system. This was published after inviting public comments and external evaluations. Consensus on clinical questions (CQs) was achieved using the modified Delphi method.

resultsThere was no change in the basic policy that all H. pylori infectious diseases are indications for eradication. Nucleic acid amplification was added to the diagnostic methods. Effects of proton-pump inhibitors (PPIs) on diagnostic tests were updated. The superiority of potassium-competitive acid blockers to PPIs in 1-week triple therapy with amoxicillin and clarithromycin has been shown. A flowchart for eradication therapy was provided for use in real-world settings. For gastric cancer prevention, eradication in earlier age is recommended. The most appropriate test and treatment strategies for adolescents are also described. Some CQs concerning gastric cancer prevention were identified, although evidence level was insufficient to make recommendations based on clinical importance.

conclusionThe revised guidelines facilitate the appropriate management of H. pylori infection and gastric cancer prevention.

Indexed as

Helicobacter InfectionsHelicobacter pyloriAnti-Bacterial AgentsDrug Therapy, CombinationHumansJapanProton Pump InhibitorsStomach NeoplasmsAnti-Bacterial AgentsProton Pump InhibitorsClinical questionsDiagnosisEradicationGastric cancer preventionHelicobacter pylori

Identifiers

PMID41902905
PMCPMC13283202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.