ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026
Chemical profiling and biological activities of the medicinal macrofungus Coriolopsis gallica: volatile, non-volatile, and fatty acid composition with antioxidant and in silico-supported anti-inflammatory properties.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCoriolopsis gallica, a medicinal macrofungus, was collected from a decaying hardwood trunk in Constantine, Algeria.
objectiveC. gallica was investigated to explore its chemical composition and biological activities.
methodsMorphological analysis confirmed characteristic features of C. gallica and GC-MS and in silico analyses were performed.
resultsChemical profiling revealed that the volatile fraction was dominated by benzyl benzoate (16.6%), and 2,4-di-tert-butylphenol (14.4%), while the non-volatile fraction was primarily lactose (90.6%) with notable aucubin (4.3%), a bioactive iridoid glycoside. Fatty acid analysis indicated high content of linoleic acid (79.0%) and oleic acid (11.8%), suggesting potential anti-inflammatory and antioxidant effects. The ethanolic extract demonstrated significant antioxidant activity in the DPPH assay (IC₅₀ = 11.28 ± 0.24 µg/mL) and moderate anti-denaturation activity (IC₅₀ = 6.75 ± 0.5 mg/mL), consistent with the presence of bioactive metabolites. Molecular docking analyses of all identified metabolites against COX-2 and 5-LOX revealed a range of predicted binding affinities and interaction patterns, with several fatty acids, including linoleic and oleic acids, showing favorable docking scores, while aucubin and phenolic compounds exhibited complementary hydrogen-bonding and hydrophobic interactions. These in silico results provide comparative, hypothesis-generating insights that complement the in vitro antioxidant and anti-denaturation assays.
conclusionOverall, the combined chemical, biological, and computational analyses highlight Coriolopsis gallica as a promising natural source of structurally diverse bioactive compounds with antioxidant and anti-inflammatory relevance, supporting its interest in early-stage natural product research.
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