Evidence map›Paper›PMID 41902852›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Protective effect of caffeic acid tetramer based on PI3K/AKT and MAPK/NF-κB signaling pathway on acute liver injury in mice.

Dongmei Qin, Xinyue Wang, Jinqiu Hou, Linjie Su, Yuefeng Gao, Jia Xu

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dongmei Qin *Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832000, People's Republic of China. qdm_pha@shzu.edu.cn.
Xinyue Wang *Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832000, People's Republic of China.
Jinqiu Hou *Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832000, People's Republic of China.
Linjie SuThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, People's Republic of China.
Yuefeng GaoCollege of Applied Engineering, Henan University of Science and Technology, Sanmenxia, 472000, People's Republic of China.
Jia XuThe First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, Xinjiang, People's Republic of China. wryd1976@sina.com.

Funding

Major Science and Technology project of Xinjiang Production and Construction Corps 2020AA005National Natural Science Foundation of China NO.81860730
6 · The paper itself

Abstract

Arnebia euchroma (Royle) Johnstn (AE) is a traditional Chinese medicine primarily produced in Xinjiang and Inner Mongolia, and it derives its medicinal attributes from the desiccated roots of AE species. Caffeic acid tetramer (CATE), the main phenolic acid monomer isolated from the aqueous extract of AE, was investigated for its liver-protecting effects and anti-inflammatory mechanisms in this study. Acute liver injury (ALI) models were established in murine using lipopolysaccharide (LPS)/d-galactosamine (D-GalN) to elucidate the effects of CATE. Prolonged pretreatment with CATE for 14 days notably decreased serum levels of inflammatory markers in ALI murine models, suggesting a significant improvement in hepatic inflammation. Moreover, reduced expression of IL-6, TNF-α, PI3K, P-Akt, P-Erk1/2, and P-P65 proteins was observed in liver tissues from the CATE pretreatment group compared to the ALI group, aligning with findings from an in vitro inflammation model. These results demonstrate the hepatoprotective and anti-inflammatory properties of CATE, which are attributed to its ability to suppress inflammatory factors and inhibit activation of the PI3K/Akt and MAPK/NF-κB pathways. This study provides a strong rationale for the therapeutic application of CATE in ameliorating ALI and establishes a foundation for its clinical exploration and development.

Indexed as

Anti-Inflammatory AgentsCaffeic AcidsChemical and Drug Induced Liver InjuryAnimalsDisease Models, AnimalGalactosamineLipopolysaccharidesLiverMaleMiceMice, Inbred C57BLNF-kappa BPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAnti-Inflammatory Agentscaffeic acidCaffeic AcidsGalactosamineLipopolysaccharidesNF-kappa BPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAcute liver injuryCaffeic acid tetramerHepatoprotective effectMAPKNF-κBPI3K/Akt

Identifiers

PMID41902852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.