Evidence map›Paper›PMID 41902828›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

Fecal microbiota transplantation mitigates cardiac remodeling and functional impairment in mice with chronic colitis.

Xiaoying S Zhong, Kevin M Lopez, Max Liu, Ying Xiao, Rongliwen Ou, Thierry Kochkarian, Don W Powell, Ken Fujise, Qingjie Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiaoying S ZhongDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.
Kevin M LopezDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.ORCID 0000-0002-3163-4634
Max LiuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.
Ying XiaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.
Rongliwen OuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.
Thierry KochkarianDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.
Don W PowellDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.ORCID 0000-0002-5618-1555
Ken FujiseHarborview Medical Center Cardiology, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-6763-8055
Qingjie LiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States.ORCID 0000-0003-1405-7000

Funding

Gut Dysbiosis and Cardiac Remodeling in IBDR01HL152683 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FUJISE, KEN, LI, QINGJIE · 2020 to 2023
$2.6M
HHS | National Institutes of Health (NIH) R01HL152683NHLBI NIH HHS R01 HL152683
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestines accompanied by profound extraintestinal manifestations. Although IBD shows a clear clinical association with cardiovascular derangements, whether and how chronic colitis impairs heart function remains unclear. To address this gap, we investigated the impact of chronic colitis on cardiac performance and the cardiac transcriptome using two mouse models: dextran sodium sulfate (DSS)-treated and

Indexed as

ColitisFecal Microbiota TransplantationGastrointestinal MicrobiomeVentricular RemodelingAnimalsChronic DiseaseDextran SulfateDisease Models, AnimalFibrosisInflammatory Bowel DiseasesInterleukin-10MaleMiceMice, Inbred C57BLMice, KnockoutMyocardiumDextran SulfateIL10 protein, mouseInterleukin-10dysbiosisfibrosisgut-heart axisheart dysfunctioninflammatory bowel disease

Identifiers

PMID41902828
PMCPMC13580357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.