Evidence map›Paper›PMID 41902663›Full record

Trial reportJournal of psychopharmacology (Oxford, England)2026

The behavioural effects of the serotonin 1A receptor agonist buspirone on reward processing in healthy volunteers: A randomised, placebo-controlled study.

Alexander L W Smith, Sorcha Hamilton, Susannah E Murphy, Philip J Cowen, Catherine J Harmer

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander L W SmithDepartment of Psychiatry, Warneford Hospital, University of Oxford, UK.ORCID 0000-0003-1052-0096
Sorcha HamiltonDepartment of Psychiatry, Warneford Hospital, University of Oxford, UK.
Susannah E MurphyDepartment of Psychiatry, Warneford Hospital, University of Oxford, UK.ORCID 0000-0001-8995-2099
Philip J CowenDepartment of Psychiatry, Warneford Hospital, University of Oxford, UK.
Catherine J HarmerDepartment of Psychiatry, Warneford Hospital, University of Oxford, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundThe 5-HT

aimsWe investigate whether acute 5-HT

methodsIn a double-blind, placebo-controlled study using a single 20 mg dose of buspirone, a serotonin 5-HT

resultsIn healthy volunteers, acute buspirone increases the aversiveness of bitter tastes, non-significantly reduces willingness to exert effort and increases optimal choice during loss trials in the PILT.

conclusionsSpeculatively, this could indicate that acute 5-HT

Indexed as

BuspironeReceptor, Serotonin, 5-HT1ARewardSerotonin 5-HT1 Receptor AgonistsAdultChoice BehaviorDouble-Blind MethodFemaleHealthy VolunteersHumansMaleMotivationTasteYoung AdultBuspironeReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Agonists5-HT1Alearningmotivationrewardserotonin

Identifiers

PMID41902663
PMCPMC13490652

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.