Evidence map›Paper›PMID 41902655›Full record

ArticleJournal of psychopharmacology (Oxford, England)2026

Administration of an extrasynaptic δ-subunit GABA

Maarten van den Buuse, Jessica Roberts, Michael T C Hunter, Gracie L Hay, Nicholas A Everett, Sarah J Baracz, Travis A Wearne, Jennifer L Cornish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maarten van den BuuseSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Jessica RobertsBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Michael T C HunterBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Gracie L HayBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Nicholas A EverettBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Sarah J BaraczBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0002-9938-1936
Travis A WearneBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
Jennifer L CornishBehavioural Neuropharmacology Laboratory, Faculty of Medicine, Health and Human Sciences, School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0002-9754-8069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsChronic methamphetamine (METH) intake is associated with a high risk of psychosis and high susceptibility to relapse following abstinence. Prelimbic cortex (PLC) extrasynaptic GABA METHODS AND

resultsIn Experiment 1, male rats received 1 week of chronic treatment with METH (1 mg/kg days 1 and 7, 5 mg/kg days 2-6) or saline, followed by 14 days withdrawal. THIP (0, 0.1, 0.3 or 1.0 μg per hemisphere) was then micro-injected into the PLC prior to challenge with METH (1 mg/kg) or saline. Acute METH challenge enhanced locomotor hyperactivity in METH-pretreated rats, confirming sensitisation. THIP administration into the PLC dose-dependently reduced the effect of acute METH challenge in METH-pretreated rats. In Experiment 2, rats were trained to intravenously self-administer METH, followed by 2 weeks of extinction. Rats were then given a METH priming injection or exposed to cues associated with METH self-administration, both of which reinstated responding on the lever previously paired with METH delivery. At the 0.3 µg dose, injection of THIP into the PLC reduced reinstatement responding in both paradigms.

conclusionSelective activation of extrasynaptic PLC δ-subunit GABA

Indexed as

Amphetamine-Related DisordersDrug-Seeking BehaviorGABA-A Receptor AgonistsMethamphetamineAnimalsCentral Nervous System StimulantsDose-Response Relationship, DrugExtinction, PsychologicalMalePrefrontal CortexRatsRats, Sprague-DawleyReceptors, GABA-ARecurrenceSelf AdministrationCentral Nervous System StimulantsGABA-A Receptor AgonistsMethamphetamineReceptors, GABA-AaddictionGABAmethamphetamineprelimbic cortexpsychosisrelapse

Identifiers

PMID41902655
PMCPMC13490680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.