Evidence map›Paper›PMID 41902610›Full record

ArticleAutism research : official journal of the International Society for Autism Research2026

Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.

Aarti Nair, Rhideeta Jalal, Katherine E Lawrence, Niharika Verma, Hector Gutierrez, Kristen Laulette, Katherine H Karlsgodt, Carrie E Bearden

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aarti NairDepartment of Psychology, Loma Linda University, Loma Linda, California, USA.ORCID 0000-0002-4058-6857
Rhideeta JalalDepartment of Psychology, Loma Linda University, Loma Linda, California, USA.
Katherine E LawrenceImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Niharika VermaDepartment of Psychology, Loma Linda University, Loma Linda, California, USA.
Hector GutierrezDepartment of Psychology, Loma Linda University, Loma Linda, California, USA.
Kristen LauletteDepartment of Psychology, University of California, Los Angeles, California, USA.
Katherine H KarlsgodtDepartment of Psychology, University of California, Los Angeles, California, USA.
Carrie E BeardenDepartment of Psychology, University of California, Los Angeles, California, USA.ORCID 0000-0002-8516-923X

Funding

Microstructural Neuroimaging of Synaptic Pruning and Myelination in Adolescent PsychosisR21MH116433 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARLSGODT, KATHERINE HELEN · 2019 to 2020
$429k
Neural Basis of Social Cognition Deficits in Youth With Autism and SchizophreniaK99MH113820 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NAIR, AARTI · 2018 to 2019
$239k
NIMH NIH HHS K99 MH113820NIMH NIH HHS K99MH113820NIMH NIH HHS R21 MH116433NIMH NIH HHS R21MH116433
6 · The paper itself

Abstract

Both autism spectrum disorder (ASD) and psychosis are associated with challenges in social cognition. The triple-network model posits that dysfunction within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) contributes to these deficits. However, the relationship between triple-network connectivity and social cognition has not been systematically compared across these groups during adolescence. We examined whole-brain functional connectivity of the triple-network in a sample of youth with ASD (N = 24), youth with early-onset psychosis (EOP; N = 25), and age-matched typically developing (TD) controls (N = 26, overall mean age = 16.39 ± 2.36, % female = 41%). Additionally, we examined relationships between connectivity patterns of the triple-network and behavioral measures of social cognition and emotion recognition in each group. ASD youth showed mixed over- and under-connectivity in the DMN, CEN overconnectivity, and SN underconnectivity, while EOP youth showed DMN and CEN overconnectivity, with relatively intact SN connectivity, compared to TD controls. Compared to EOP, ASD participants had reduced SN connectivity and mixed disruptions in DMN connectivity. Across groups, connectivity patterns were linked to social behaviors: in EOP, DMN overconnectivity was associated with poorer social cognition; in ASD, SN underconnectivity was associated with poorer social cognition. These findings highlight both shared and distinct patterns of triple-network dysconnectivity in ASD and EOP, supporting transdiagnostic models of social cognitive dysfunction, and reinforcing adolescence as a key developmental window for network-based brain changes.

Indexed as

Autism Spectrum DisorderBrainNerve NetPsychotic DisordersSocial CognitionAdolescentBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeural Pathwaysautism spectrum disorderearly‐onset psychosisfunctional connectivityresting‐statesocial cognition

Identifiers

PMID41902610
PMCPMC13657677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.