ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Immune and Stem Cell-Mediated Bactericidal Amplification and Bone Remodeling for Infection Clearance and Osteointegration.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Interfacial mild alkalinity shapes Neutrophil immunometabolism through sphingolipid remodeling to enhance antibacterial host defense.Materials today. Bio · 2026Article
- Bioorthogonal Anchor-and-Lock of Probiotic Biofilms on Diverse Biomaterials to Combat Delayed Implant-Associated Infection.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants.Materials today. Bio · 2026Article
- Periprosthetic joint infection as failure of containment: A causal and probabilistic framework.Journal of orthopaedic translation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Implant-related infections reduce mesenchymal stem cell accumulation near implant sites while suppressing the viability and osteogenic capacity of these stem cells. Here, we show that pH-responsive biomaterial interfaces exploit infection-induced acidification to coordinate antimicrobial action with stem and immune cell functional reprogramming. The system can release bactericidal peptides for direct bacterial elimination, whereas indirect bactericidal enhancement occurs in the presence of magnesium ions and cell-targeting peptides, which enable a positive modulation of immune responses and recruitment of bone marrow mesenchymal stem cells, respectively. This feature results in robust osteogenic differentiation at the implant interfaces, achieving a 280% increase in the interfacial bone volume in rat infection models. Through transcriptomic analysis, we also show that Wnt-activated stem cells and alternatively activated macrophages jointly upregulate antimicrobial effector programs along with osteogenic genes, contributing to the observed >4-log bacterial reduction through combined material- and cell-mediated suppression. The coordinated infection clearance and interface regeneration demonstrate that infection-responsive biomaterials can transform endogenous cells to bifunctional therapeutic agents, defining a strategy that addresses infection and regeneration as integrated biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.