Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides.

Katherine G Rodden, Agamemnon E Crumpton, Samuel E Dalton, Michael A Clegg, Michael C Willis

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katherine G RoddenDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.

Agamemnon E CrumptonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.

Samuel E DaltonDiscovery Chemistry, MSD (UK) Limited, London, UK.

Michael A CleggDiscovery Chemistry, MSD (UK) Limited, London, UK.

Michael C WillisDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0636-6471

Funding

GSK, MSD, Syngenta, and Vertex

6 · The paper itself

Abstract

Acrylamides are the dominant electrophilic warheads used in bioactive covalent inhibitors. A limitation of acrylamides and related unsaturated sulfonamides is the narrow scope to modulate their electrophilicity, and hence reactivity, through simple structural modification. Here, we show that vinyl sulfondiimidamides are effective electrophilic motifs for reaction with both sulfur- and nitrogen-based biologically relevant nucleophiles. We demonstrate that the electrophilicity of these new reagents can be tuned through variation of the imidic N-substituents. Vinyl sulfondiimidamides are prepared via a short sequence that features a Cope elimination as the key alkene-forming step. A broad range of N-substituents can be installed.

Indexed as

covalent warheadscysteineelectrophilessulfur functional groupssynthetic methods

Identifiers

PMID41902535

DOI10.1002/anie.9885717

PMCPMC13134591

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.