ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026
Maternal low-sodium diet impairs hippocampal neurogenesis and cognition in adult mouse offspring.
Xingrao Ke, Connie C Grobe, Justin L Grobe, Wei Yu, John J Reho, Kaela M Varberg, Robert H Lane, Jeffrey L Segar
Abstract read
In one paragraphArticle in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Xingrao KeFetal Health Center, Children's Mercy Hospital, Kansas City, Missouri, United States.
Connie C GrobeDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Justin L GrobeDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-9737-0873 Wei YuDivision of Neonatology, Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, United States.
John J RehoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Kaela M VarbergFetal Health Center, Children's Mercy Hospital, Kansas City, Missouri, United States.ORCID 0000-0001-9672-4158 Robert H LaneDepartment of Administration, Children's Mercy Hospital, Kansas City, Missouri, United States.
Jeffrey L SegarDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-7311-8948 Funding
Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MImpact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9MRegulation of Invasive Trophoblast Cell Lineage DevelopmentR00HD107262 · NICHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI VARBERG, KAELA MARGARET · 2023 to 2025
$740kAdvancing a Healthier Wisconsin Endowment (AHW)Children's Mercy Hospital (CMH)HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD107262HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001436HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL134850HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK133121Medical College of Wisconsin (MCW)Mellowes and Butenhoff EndowmentsNCATS NIH HHS UL1 TR001436NHLBI NIH HHS R01 HL134850NICHD NIH HHS R00 HD107262NIDDK NIH HHS R01 DK133121
6 · The paper itselfAbstract
Sodium (Na) homeostasis is critical for organ and cell function. Although low maternal Na intake during gestation is associated with low offspring survival rates and birth weights, the long-term impact on neurocognitive function is not known. Identifying a relationship between perinatal Na dysregulation and adult behavioral and cognitive outcomes may be important given the prevalence of both dysnatremias and neurocognitive impairment in preterm infants. This study aimed to determine the association between maternal low Na intake (LSI) and hippocampal-dependent behaviors in mice. C57BL/6J dams were fed a standard (0.30%) or low (0.04%) Na diet from
Indexed as
CognitionDiet, Sodium-RestrictedHippocampusMaternal Nutritional Physiological PhenomenaNeurogenesisPrenatal Exposure Delayed EffectsAnimalsBehavior, AnimalDevelopmental Origins of Health and DiseaseEpigenesis, GeneticFemaleMaleMiceMice, Inbred C57BLPregnancySOXB1 Transcription FactorsSox2 protein, mouseSOXB1 Transcription Factorsbehaviorepigeneticsoffspringprogrammingsodium
Identifiers
PMID41902531
PMCPMC13160179
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