Evidence map›Paper›PMID 41902441›Full record

ArticleActa obstetricia et gynecologica Scandinavica2026

The effect of labor epidural analgesia on uterine activity using electrohysterography monitoring: A follow-up study.

Phebe B Q Berben, Yannick L Smolders, Ivar R de Vries, Nadine D de Klerk, Annemarie F Fransen, Marta Regis, M Beatrijs van der Hout-van der Jagt, Myrthe van der Ven, Alexandra M J V Schyns-van den Berg, S Guid Oei and 1 more

Abstract read
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Phebe B Q BerbenDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0009-0004-7909-3795
Yannick L SmoldersDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0009-0001-2203-3933
Ivar R de VriesDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.
Nadine D de KlerkDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.
Annemarie F FransenDepartment of Obstetrics and Gynecology, Zuyderland Medical Center, Heerlen, The Netherlands.
Marta RegisDepartment of Research and Medical Innovation, Máxima Medical Center, Veldhoven, The Netherlands.
M Beatrijs van der Hout-van der JagtDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0000-0002-5805-5333
Myrthe van der VenDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.
Alexandra M J V Schyns-van den BergDepartment of Anesthesiology, LUMC, Leiden, The Netherlands.
S Guid OeiDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.
Judith O E H van LaarDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.

Funding

Máxima MC Fund 2023.coi.006ZonMw - The Highly Specialized Care & Research Program, The Hague, The Netherlands 10070022010001
6 · The paper itself

Abstract

introductionLabor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear. Electrohysterography (EHG) is a promising non-invasive method for intrapartum UA monitoring. The aim of this study was to explore the effect of LEA on UA by means of EHG, to develop better understanding of labor physiology, and inform clinical decision-making. MATERIAL AND

methodsPatients in active labor with singleton, term pregnancies who received electrophysiological monitoring from 60 min before until 120 min after LEA initiation were included. Contraction parameters such as frequency, duration, area under the curve (AUC), baseline, and maximum amplitude were obtained from an EHG-derived tocogram using a computer-based algorithm. The primary outcome was the difference in mean uterine contraction frequency before and after initiation of LEA. Secondary outcomes included the comparison of various contraction parameters, derived from EHG, before and after LEA initiation, as well as their temporal changes over time. The effect of possible confounders on UA was examined. Mixed effects models were used for statistical analyses.

resultsIn total, 86 patients were included. No significant difference in mean uterine contraction frequency and contraction duration was found before and after LEA initiation. Nevertheless, start of LEA was associated with a significant reduction in AUC, baseline activity, and signal amplitude.

conclusionsLEA initiation does not affect uterine contraction frequency or duration, but it is associated with a significant reduction in relative EHG-derived amplitude parameters (AUC, baseline tone, and maximum amplitude), which could potentially affect progression of labor. Further studies are required to explore these parameters and their clinical implications.

Indexed as

Analgesia, EpiduralAnalgesia, ObstetricalLabor, ObstetricUterine ContractionUterine MonitoringAdultElectromyographyFemaleFollow-Up StudiesHumansPregnancyelectrohysterographyepidural analgesiafirst labor stageuterine contractionuterine monitoring

Identifiers

PMID41902441
PMCPMC13125345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.