Evidence map›Paper›PMID 41902404›Full record

ArticleBiophysical journal2026

A cationic single-chain bolalipid forms stable vesicles with distinct interfacial behavior.

Preeti Gahtori, Hossein Varghaei, Bibhas Hazra, Christian Jankovic, Jonathan Strobl, Harpreet Kaur, Sara Khamis, Frederick G West, Julianne M Gibbs, Sheref S Mansy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Preeti GahtoriDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Hossein VarghaeiDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Bibhas HazraDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Christian JankovicDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Jonathan StroblDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Harpreet KaurDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Sara KhamisDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Frederick G WestDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Julianne M GibbsDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Sheref S MansyDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada. Electronic address: sheref.mansy@unitn.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of single-chain bolalipids (or bolaamphiphiles) to self-assemble into vesicular structures remains poorly characterized. Here, we report the synthesis and self-assembly behavior of a new class of proline-based single-chain lipids, a symmetric bipolar molecule (2Pro-C18:1) and, for comparison, a unipolar analog (1Pro-C18:1), both bearing an unsaturated C18 hydrocarbon chain. Confocal fluorescence microscopy, encapsulation assays, and fluorescence spectroscopy demonstrate that both amphiphiles form stable vesicles capable of entrapping small molecules. Vesicle formation occurs over a broad range of pH values, with the bolalipid favoring higher pH, consistent with differences in apparent pK

Indexed as

LipidsAirCationsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsSurface PropertiesWaterCationsLipidsWater

Identifiers

PMID41902404
PMCPMC13351563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.