SFV Replicon Vector Harbouring Porcine Epidemic Diarrhoea Virus Immunogens Delivered by Attenuated

Chamith Hewawaduge, Ji-Young Park, Jaime C Cabarles, Gayeon Won, John Hwa Lee

Abstract read

In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chamith HewawadugeSri Lanka Institute of Biotechnology, Pitipana, Homagama 10200, Sri Lanka.

Ji-Young ParkDivision of Zoonotic and Vector Borne Disease Research, National Institute of Health, Korea Disease Control and Prevention Agency, Osong, Cheongju 28160, Republic of Korea.

Jaime C CabarlesCollege of Agriculture, Resources and Environmental Science, Central Philippine University, Jaro, Iloilo City 5000, Philippines.

Gayeon WonCollege of Veterinary Medicine, Jeonbuk National University, Iksan Campus, Iksan 54596, Republic of Korea.

John Hwa LeeCollege of Veterinary Medicine, Jeonbuk National University, Iksan Campus, Iksan 54596, Republic of Korea.ORCID 0000-0002-2028-2207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPorcine epidemic diarrhoea virus (PEDV) is a highly contagious pathogen causing severe diarrhoea and high mortality in neonatal piglets.

methodsIn this study, consensus sequences encoding the N-terminal domain of spike subunit 1 (S1-NTD) and nucleocapsid (N) protein of PEDV were cloned into a eukaryotic expression vector pJHL204 and transformed into an attenuated

resultsVaccinated mice exhibited no adverse effects or bacterial persistence in major organs, confirming the vaccine's safety. Immunisation elicited robust PEDV- and

conclusionOur findings indicate that the designed vaccine constructs provide a promising platform for inducing multifaceted immuno-protectivity against PEDV and salmonellosis.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCoronavirus InfectionsImmunogenicity, VaccinePorcine epidemic diarrhea virusSalmonella typhimuriumViral VaccinesAnimalsFemaleGenetic VectorsImmunization, PassiveMiceMice, Inbred BALB CPicornaviralesSpike Glycoprotein, CoronavirusSwineAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, CoronavirusViral Vaccineshumoral and cell-mediated immunitylactogenic immunityneutralising antibodiesPED virusSalmonella Typhimuriumsalmonellosis

Identifiers

PMID41902283

DOI10.3390/v18030375

PMCPMC13030594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.