Evidence map›Paper›PMID 41902270›Full record

ReviewViruses2026

Cell-Mediated Immunity Against Human Papillomavirus Infection: From Viral Clearance to Oncogenesis.

Diana Savage, Jiafen Hu, Adam D Burgener, Afshin Raouf, Thomas T Murooka

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diana SavageDepartment of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Jiafen HuDepartment of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-8700-9937
Adam D BurgenerCenter for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Afshin RaoufDepartment of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Thomas T MurookaDepartment of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.ORCID 0000-0002-3030-2726

Funding

A co-infection model for papillomavirus associated infections and cancersR21CA274265 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILBERT, NICOLE MARIE, HU, JIAFEN · 2023 to 2024
$433k
Role of estrous cycle and contraceptives in anogenital papillomavirus infectionR21AI121822 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRISTENSEN, NEIL D, HU, JIAFEN · 2016 to 2017
$425k
The role of bacterial vaginosis-associated bacteria in papillomavirus persistence and cancersR21CA271069 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HU, JIAFEN, MUROOKA, THOMAS T. · 2022 to 2023
$393k
CIHR BH6-198724CIHR PJT-197796NIH HHS R21 AI121822NIH HHS R21 CA271069NIH HHS R21 CA274265
6 · The paper itself

Abstract

Human papillomavirus (HPV), especially high-risk HPV types, is a significant public health concern due to its association with various cancers and increased risk of acquiring other sexually transmitted infections (STIs). In most cases, host immunity rapidly responds to and clears HPV infections, but persistent or latent infections can increase susceptibility to cancer. A better understanding of how HPV interacts with and evades the immune response is vital to understanding disease progression and guiding the next generation of vaccines and immunotherapies. This review article provides a comprehensive overview of the immune mechanisms involved in HPV infection, highlighting the roles of T cells and other immune subsets. We discuss the immune evasion strategies employed by HPV and subsequent modulation of the immune microenvironment. Additionally, we explore the current therapeutic landscape and emerging immunotherapeutic approaches under investigation. By unveiling the intricacies of the immune response to HPV, we may inform improved strategies for the treatment of HPV-related diseases.

Indexed as

CarcinogenesisHuman Papillomavirus VirusesImmunity, CellularPapillomavirus InfectionsAnimalsHost-Pathogen InteractionsHumansImmune EvasionImmunotherapyPapillomaviridaeT-Lymphocytescell-mediated immunitycutaneous infectionhuman papillomavirusimmunotherapymucosal infectionT cell response

Identifiers

PMID41902270
PMCPMC13030260

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.