Evidence map›Paper›PMID 41902200›Full record

ArticleViruses2026

Analysis of Recombinant Cedar Virus Infection and Cross-Protection Against Related Henipaviruses in African Green Monkeys.

Declan D Pigeaud, Moushimi Amaya, Viktoriya Borisevich, Karla A Fenton, Krystle N Agans, Courtney Woolsey, Antony S Dimitrov, Abhishek N Prasad, Natalie S Dobias, Daniel J Deer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Declan D PigeaudGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-7130-6144
Moushimi AmayaDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.
Viktoriya BorisevichGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Karla A FentonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Krystle N AgansGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-7319-6935
Courtney WoolseyGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-3389-0137
Antony S DimitrovDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.ORCID 0000-0001-8356-6701
Abhishek N PrasadGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-4147-2077
Natalie S DobiasGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Daniel J DeerGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Joan B GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Robert W CrossGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Christopher C BroderDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.ORCID 0000-0001-5382-0510
Thomas W GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-0858-1877

Funding

Project 3 - USUHSU19AI142764 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI ZEITLIN, LARRY · 2019 to 2023
$24.6M
UTMB Women's Health Research Scholars ProgramK12AR084228 · NIAMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ABBEY B BERENSON · 2023 to 2026
$2.7M
National Institute of Allergy and Infectious Diseases U19AI142764National Institute of Allergy and Infectious Diseases U19AI181930NIAID NIH HHS U19 AI142764NIAMS NIH HHS K12 AR084228
6 · The paper itself

Abstract

Cedar virus (CedV), related to the highly pathogenic bat-borne henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), is non-pathogenic in small animal models, likely due to the inability to produce interferon-antagonist proteins. We evaluated the pathogenesis of recombinant CedV (rCedV) in the African green monkey (AGM) model and determined if prior infection conferred cross-protective immunity against a lethal challenge with NiV Bangladesh (NiV-B) or HeV. AGMs infected with rCedV remained asymptomatic, with no clinical signs of disease or detectable viremia. The rCedV infected animals developed homologous neutralizing antibody responses that failed to cross-neutralize NiV-B or HeV. At 42 days post-rCedV infection, AGMs were challenged with a lethal dose of NiV-B or HeV, and prior infection with rCedV failed to protect against NiV-B challenge, with all animals succumbing to NiV-B. Similarly, rCedV infection did not confer consistent protection against HeV, with 2/4 animals succumbing to lethal HeV. These findings confirm that CedV is non-pathogenic in the AGM model of NiV and HeV infection, justifying its classification as a BSL-2 agent. The findings also demonstrate that rCedV does not elicit a cross-protective immune response to prevent lethal disease from either NiV-B or HeV highlighting significant immunological differences between CedV and the pathogenic henipaviruses.

Indexed as

Cross ProtectionHenipavirusHenipavirus InfectionsAnimalsAntibodies, NeutralizingAntibodies, ViralChlorocebus aethiopsDisease Models, AnimalHendra VirusNipah VirusAntibodies, NeutralizingAntibodies, Viralanimal modelCedar viruscross-protectionHendra virusintranasal routeintratracheal routeNipah virusnonhuman primatepathogenesis

Identifiers

PMID41902200
PMCPMC13030515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.