Evidence map›Paper›PMID 41901961›Full record

ArticleSensors (Basel, Switzerland)2026

Direct Evidence for the Feedforward Neurovascular Coupling Mechanism in Humans During Task Onset: An EEG-fNIRS-TCD Multimodal Imaging Study.

Joel S Burma, Matthew G Neill, Elizabeth K S Fletcher, Jina Seok, Nathan E Johnson, Kathryn J Schneider, Chantel T Debert, Jeff F Dunn, Jonathan D Smirl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joel S BurmaCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0001-9756-5793
Matthew G NeillCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0009-0000-5397-208X
Elizabeth K S FletcherCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0009-0000-6557-2913
Jina SeokCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
Nathan E JohnsonCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
Kathryn J SchneiderAlberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0002-5951-5899
Chantel T DebertAlberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0002-2704-0438
Jeff F DunnIntegrated Concussion Research Program, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0001-9728-2654
Jonathan D SmirlCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0003-1054-0038

Funding

CIHR 173416Natural Sciences and Engineering Research Council of Canada CGSD3-559333-2021Natural Sciences and Engineering Research Council of Canada RGPIN-2020-04057
6 · The paper itself

Abstract

This investigation assessed the neurovascular coupling response through integrated assessments of neuronal function [electroencephalography (EEG)], microvascular oxygenation concentrations [functional near-infrared spectroscopy (fNIRS)], and arterial responses [transcranial Doppler ultrasound (TCD)]. The NVC response was assessed in 113 participants (86 females, aged 19-40 years) during visual ("Where's Waldo?") and motor (finger tapping) tasks. Block-averaged, time-frequency power was computed from the EEG data, while hemodynamic response functions were obtained from the fNIRS and TCD metrics. Granger causality assessed the predictiveness between EEG-fNIRS-TCD waveforms for each participant and was converted into a percentage of individuals displaying a significant value. Linear models were computed to determine the influence of sex, concussion history, young adulthood age, cardiorespiratory fitness, and mental health/learning disabilities on NVC parameters. During the initial 10 s of task onset, unidirectional predictiveness was weak to very strong for EEG-TCD (range: 47-83%) and fNIRS-TCD (44-92%) relationships; however, very weak to weak predictiveness was seen for the E0EG-fNIRS (0-29%) relationship for both tasks. Aside from known sex-, age-, and fitness-based influences on baseline/peak hemodynamic values (

Indexed as

ElectroencephalographyMultimodal ImagingNeurovascular CouplingUltrasonography, Doppler, TranscranialAdultFemaleHemodynamicsHumansMaleSpectroscopy, Near-InfraredYoung Adultelectroencephalographyfunctional near-infrared spectroscopyneurovascular couplingsex differencestranscranial Doppler ultrasound

Identifiers

PMID41901961
PMCPMC13029937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.