Evidence map›Paper›PMID 41901785›Full record

ArticlePathogens (Basel, Switzerland)2026

Potential Activity of 6-Pentyl-α-pyrone as an Antiviral for Bovine Coronavirus.

Luca Del Sorbo, Rosa Giugliano, Clementina Acconcia, Maria Michela Salvatore, Alessia Staropoli, Violetta Iris Vasinioti, Maria Stella Lucente, Paolo Capozza, Francesco Vinale, Annamaria Pratelli and 3 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luca Del SorboDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.
Rosa GiuglianoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0001-9923-3194
Clementina AcconciaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.
Maria Michela SalvatoreDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0001-8318-3065
Alessia StaropoliDepartment of Agricultural Sciences, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-8946-1609
Violetta Iris VasiniotiDepartment of Veterinary Medicine, University of Bari, 70010 Bari, Italy.ORCID 0000-0002-3798-0407
Maria Stella LucenteDepartment of Veterinary Medicine, University of Bari, 70010 Bari, Italy.ORCID 0000-0002-5955-8338
Paolo CapozzaDepartment of Veterinary Medicine, University of Bari, 70010 Bari, Italy.ORCID 0000-0001-5563-1131
Francesco VinaleDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-5090-8127
Annamaria PratelliDepartment of Veterinary Medicine, University of Bari, 70010 Bari, Italy.ORCID 0000-0001-6862-1792
Luigi RussoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.ORCID 0000-0002-1577-176X
Rosa IacovinoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.ORCID 0000-0001-7792-9342
Filomena FioritoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-6658-7807

Funding

"Coronavirosi nei ruminanti domestici nel sud Italia: descrizione di casi di infezioni zoono-tiche inverse" Project IZS ME 03-22 RCEuropean Union-Next-Generation EU, "Antiviral activity of drugs and natural compounds evaluated in vitro and in vivo against bovine coronavirus: a translational study to SARS-CoV-2" Project PRIN Prot. 2022WTWB9R
6 · The paper itself

Abstract

During infection in vitro with the strain 438/06 of bovine coronavirus (BCoV), a β-coronavirus similar to severe acute respiratory syndrome (SARS) CoV-2, treatment with 6-pentyl-α-pyrone (6PP), a fungal metabolite obtained from

Indexed as

Antiviral AgentsCoronavirus, BovineCoronavirus InfectionsPyronesAnimalsCattleCell LineCell SurvivalMolecular Docking SimulationVirus InternalizationAntiviral AgentsPyrones6PPAhRantiviral activityBCoVin silicoin vitroMDBK

Identifiers

PMID41901785
PMCPMC13029080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.