Evidence map›Paper›PMID 41901758›Full record

ArticlePathogens (Basel, Switzerland)2026

Microbiological Characteristics and Clinical Outcomes of Periprosthetic Infections Following Oncologic Megaprosthetic Reconstruction: A Retrospective Cohort Study.

Vasileios Karampikas, Stavros Goumenos, Andreas G Tsantes, Ioannis G Trikoupis, Panayiotis Gavriil, Anastasios G Roustemis, Alexandros Zikopoulos, Vasileios Petrakis, Dimitrios V Papadopoulos, Petros Ioannou and 3 more

Abstract read
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In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vasileios KarampikasFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0009-0002-4082-1906
Stavros GoumenosLeeds Major Trauma Centre, Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX, UK.
Andreas G TsantesLaboratory of Haematology and Blood Bank Unit, University General Hospital "Attiko", School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0002-3695-0759
Ioannis G TrikoupisFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0003-4759-4814
Panayiotis GavriilFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Anastasios G RoustemisFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0003-1685-5559
Alexandros ZikopoulosFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Vasileios Petrakis2nd University Department of Internal Medicine, Department of Infectious Diseases, University General Hospital Alexandroupolis, Democritus University Thrace, 691 00 Komotini, Greece.
Dimitrios V PapadopoulosSecond Department of Orthopaedic Surgery, School of Medicine, Konstantopouleio General Hospital, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Petros IoannouSchool of Medicine, University of Crete, 710 03 Heraklion, Greece.ORCID 0000-0003-1082-5674
Olga SavvidouFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0002-0733-6565
Vasileios KontogeorgakosFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0001-6356-4346
Panayiotis J PapagelopoulosFirst Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, 106 79 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriprosthetic joint infection (PJI) is a severe complication following megaprosthetic reconstruction in musculoskeletal oncology. This study aimed to evaluate outcomes of different surgical strategies for PJI in lower-limb megaprostheses and identify factors associated with treatment failure.

methodsWe performed a retrospective cohort study of 29 consecutive patients treated for PJI after oncologic megaprosthetic reconstruction. Reinfection was analyzed using cumulative incidence functions (CIFs) with death treated as a competing event. Overall survival was assessed using Kaplan-Meier analysis. Univariable cause-specific Cox regression was performed for exploratory risk-factor analysis.

resultsAmong 29 patients, coagulase-negative staphylococci and

conclusionsTwo-stage revision remains the most effective strategy for PJI management in megaprostheses. DAIR may control acute infection but is suboptimal for definitive treatment. Individualized, multidisciplinary approaches are essential to improve outcomes in this high-risk population.

Indexed as

Prosthesis-Related InfectionsAgedAnti-Bacterial AgentsFemaleHumansMaleMiddle AgedReoperationRetrospective StudiesRisk FactorsTreatment OutcomeAnti-Bacterial Agentsantimicrobial therapybiofilm-associated infectiondifficult-to-treat pathogensmegaprosthesesperiprosthetic joint infectionpolymicrobial infectiontwo stage revision

Identifiers

PMID41901758
PMCPMC13029713

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.