Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages.

Yuxia Sha, Xiaoman Zhao, Hongying Zhu, Ye Li, Meilin Shao, Shenggang Ding, Haoquan Zhou

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxia ShaDepartment of Pediatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230088, China.

Xiaoman ZhaoAnhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China.

Hongying ZhuAnhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China.

Ye LiTuberculosis Department 1, Anhui Chest Hospital, Hefei 230022, China.

Meilin ShaoDepartment of Physiology, School of Basic Medicine, Anhui Institute of Medicine, Hefei 230601, China.

Shenggang DingDepartment of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

Haoquan ZhouDepartment of Pediatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230088, China.

Funding

Anhui Provincial Key Research and Development Project 2022j11020003National Natural Science Foundation of China 52273113National Natural Science Foundation of China 62276244

6 · The paper itself

Abstract

Pulmonary tuberculosis (TB) remains a major global health challenge. The molecular and metabolic responses of monocyte-derived macrophages (MDMs), which are critical for host defense against

Indexed as

Linoleic AcidMacrophagesMacrophages, AlveolarMetabolomicsTranscriptomeTuberculosis, PulmonaryAnimalsBiomarkersDisease Models, AnimalFemaleGene Expression ProfilingLungMetabolomeMiceMice, Inbred BALB CMultiomicsBiomarkersLinoleic Acidmonocyte-derived macrophagetranscriptomicstuberculosisuntargeted metabolomics

Identifiers

PMID41901707

DOI10.3390/pathogens15030254

PMCPMC13029415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.