Evidence map›Paper›PMID 41901696›Full record

ArticlePathogens (Basel, Switzerland)2026

The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.

Yan Yan, Xiang Ren, Yishu Xiao, Fang Li, Jianhui Guo, Kai Ji, Zhiping Hei, Zhijie Zhang, Yuning Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan YanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.ORCID 0009-0005-5892-9992
Xiang RenDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.ORCID 0009-0006-9603-5591
Yishu XiaoThe Third Clinical Medical College of Ningxia Medical University, People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750002, China.
Fang LiDepartment of Respiratory and Critical Care, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 750004, China.
Jianhui GuoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Kai JiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Zhiping HeiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.ORCID 0009-0009-3155-662X
Zhijie ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Yuning SunDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.ORCID 0000-0001-8867-8462

Funding

Key Research & Development Program of Ningxia Province No. 2022BEG03112National Natural Science Foundation of China No. 32560041Natural Science Foundation of Ningxia Province No. 2024AAC03512
6 · The paper itself

Abstract

Minute virus of canines (MVC) is an autonomous canine parvovirus that causes severe pathological outcomes, including embryo mortality, spontaneous abortion, and congenital malformations in neonatal puppies. Although MVC infection has been shown to induce host cell cycle arrest and apoptosis, the underlying regulatory mechanisms that coordinate cell proliferation and control apoptotic responses during viral replication remain poorly understood. Sirtuin 1 (SIRT1) is an NAD

Indexed as

BocavirusParvoviridae InfectionsSirtuin 1Tumor Suppressor Protein p53Virus ReplicationAcetylationAnimalsApoptosisCell LineDogsSirtuin 1Tumor Suppressor Protein p53apoptosisMVCp53 deacetylationSIRT1viral replication

Identifiers

PMID41901696
PMCPMC13028985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.