Evidence map›Paper›PMID 41901647›Full record

ReviewMedicina (Kaunas, Lithuania)2026

Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review.

Gulnara Ispossunova, Dejan Nikolic, Mirzakarim Alchinbayev, Ardak Nurbakyt, Akmaral Aitmanbetova, Marta Bizic, Milan Lackovic, Filip Milanovic, Aiym Amangeldi, Anel Ispossunova and 1 more

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gulnara IspossunovaDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0009-0007-3644-2029
Dejan NikolicDepartment of Physical Medicine and Rehabilitation, University Children's Hospital, 11000 Belgrade, Serbia.ORCID 0000-0002-0609-9916
Mirzakarim AlchinbayevDepartment of Urology, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.
Ardak NurbakytDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.
Akmaral AitmanbetovaDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.
Marta BizicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Milan LackovicHarris Birthright Research Centre for Fetal Medicine, King's College Hospital, London SE5 8BB, UK.ORCID 0000-0003-4446-3886
Filip MilanovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-4530-998X
Aiym AmangeldiSchool of General Medicine-2 Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0009-0005-4718-3195
Anel IspossunovaMedical Center "DNA", Kostanay 110000, Kazakhstan.ORCID 0009-0005-2510-6906
Jovana Kuzmanovic PficerSchool of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this review is to synthesize current knowledge and evidence on male reproductive health by addressing preventive medicine strategies and biomarkers, as well as to provide clinicians, researchers, and policy makers with a coherent framework for prevention of male reproductive health. In this review male (in)fertility and determinants of male reproductive health as well as preventive strategies with special attention to primary, secondary and tertiary prevention in male reproductive health will be analyzed. From primary preventive measures: education, weight management, physical activity, sleep, healthy diet, alcohol and smoking consumption will be assessed, while from secondary preventive measures: sexually transmitted infection (STI) from the point of transmission prevention, testicular self-examination, hormonal testing and management, chronic diseases and semen analysis will be discussed; and from tertiary preventive measures: treatment of STI, treatment of congenital abnormalities, infertility treatment and urogenital cancer treatment will be elaborated. Additionally, biomarkers in male reproductive health will be synthesized and discussed. Bridging the gap between evidence and practice will ultimately lead to better understanding of the complex state of male reproductive health, thus minimizing the potential missed windows of opportunities in timely adequate preventive interventions implementations, as well as on time diagnostic and optimal treatment options.

Indexed as

BiomarkersReproductive HealthHumansInfertility, MaleMaleSexually Transmitted DiseasesBiomarkersbiomarkerschallengesdiagnosticsmale reproductive healthpreventiontreatment

Identifiers

PMID41901647
PMCPMC13028458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.