ReviewMedicina (Kaunas, Lithuania)2026
Fractional Flow Reserve Derived from a Single Angiographic View: Fact or Fiction?
Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate assessment of the functional significance of coronary artery stenoses is essential for guiding revascularization decisions and improving clinical outcomes in patients with coronary artery disease (CAD). While invasive wire-based fractional flow reserve (FFR) remains the gold standard for physiological lesion assessment, its adoption in routine clinical practice is limited by procedural complexity, patient discomfort, time consumption, and cost. These limitations have driven the development of angiography-derived FFR techniques that enable physiological evaluation without pressure wires or pharmacologic hyperaemia. Recent advances in computational modelling, artificial intelligence, and image processing have facilitated the estimation of FFR from conventional coronary angiography, including approaches that require only a single angiographic view. Single-view angiography-derived FFR methods-such as Murray law-based quantitative flow ratio (µQFR), FFR2D, Angio-iFR/FFR, sAccuFFR, and X1-FFR-aim to simplify workflow while maintaining diagnostic accuracy. Among these, µQFR has demonstrated the most consistent validation against invasive FFR across a broad range of clinical scenarios, including complex lesions, severe aortic stenosis, multivessel disease, and acute coronary syndromes. This review summarizes the principles, validation data, clinical applications, and limitations of single-view angiography-derived FFR technologies and highlights their potential to expand the adoption of physiology-guided coronary intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.