Evidence map›Paper›PMID 41901040›Full record

ArticleLife (Basel, Switzerland)2026

Acute Biochemical Responses to Competitive Tournament Load in Female Handball Players: Hormonal, Inflammatory and Muscle Damage Markers.

Zarife Pancar, Yücel Makaracı, Celal Gençoğlu, Burak Karaca, Hasan Ulusal

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zarife PancarDepartment of Physical Education and Sports, Faculty of Sports Science, Gaziantep University, Gaziantep 27350, Türkiye.ORCID 0000-0002-1659-2157
Yücel MakaracıDepartment of Coaching Education, Faculty of Sports Sciences, Karamanoğlu Mehmetbey University, Karaman 70100, Türkiye.ORCID 0000-0002-6891-9916
Celal GençoğluDepartment of Physical Education and Sports Teaching, Faculty of Sport Sciences, Dokuz Eylül University, İzmir 35390, Türkiye.ORCID 0000-0001-5568-1331
Burak KaracaInstitute of Health Sciences, Department of Physical Education and Sports, Gaziantep University, Gaziantep 27310, Türkiye.ORCID 0000-0002-0597-5689
Hasan UlusalDepartment of Medical Biochemistry, Faculty of Medicine, Gaziantep Islam Science and Technology University, Gaziantep 27010, Türkiye.ORCID 0000-0003-3890-2088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongested tournament schedules impose substantial physiological stress in team sports; however, the integrated endocrine and inflammatory responses to real competitive match load in female handball players remain insufficiently characterized.

objectiveThis study aimed to characterize the acute biochemical responses, including hormonal, inflammatory, muscle damage, and bone metabolism markers, elicited by competitive tournament load in female handball players and to provide practical insights for optimizing recovery strategies and load management during short-term competitive periods.

methodsIn a pre-post study design, venous blood samples were collected from competitive female athletes (n = 8; age 20.83 ± 2.93 years) before the first match and after the fourth consecutive match of an official university qualification tournament. Biochemical analyses included cortisol, insulin, IL-6, creatine kinase (CK), IGF-1, irisin, lactate dehydrogenase (LDH), osteocalcin, and testosterone. Pre-to-post changes were assessed using paired

resultsTournament load induced substantial multisystem physiological perturbations. Significant increases were observed in cortisol (

conclusionsThese findings demonstrate that congested tournament schedules provoke an integrated endocrine-inflammatory stress response in female handball players. Importantly, the observed anabolic-catabolic imbalance highlights the need for individualized recovery strategies, optimized load management, and adequate recovery periods to mitigate maladaptation and reduce injury risk during short-term competitive tournaments.

Indexed as

female athleteshandballhormonal responseinflammationmuscle damage

Identifiers

PMID41901040
PMCPMC13028009

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.