A Novel Hybrid CNN-ViT-Based Bi-Directional Cross-Guidance Fusion-Driven Breast Cancer Detection Model.

Accurate and early identification of breast cancer from mammography is key to reducing breast cancer mortality, and automated analysis is challenging due to subtle lesion appearances, heterogeneous breast density, and the variance caused by modality. Standard Convolutional Neural Networks (CNNs) are excellent at capturing localized textures, whereas Vision Transformers (ViTs) capture long-range dependencies; however, both often struggle to produce a unified representation that consistently supports diagnostic decision-making. To address these limitations, this study presents a dual-stream framework integrating ConvNeXt for high-fidelity local feature extraction with Swin Transformer V2 for hierarchical global context modeling. A Bi-Directional Cross-Guidance (BDCG) mechanism is added to harmonize interactions between the two feature domains and ensure mutual information learning in the representations. Furthermore, a Prototype-Anchored Similarity Head (PASH) is used to stabilize classification using distance-based reasoning instead of using linear separation. Comprehensive experiments show the effectiveness of the proposed method using two benchmark datasets. On Dataset 1, the model achieves accuracy: 98.8%, precision: 98.7%, recall: 98.6%, and F1 score: 97.2%, outperforming existing models based on CNN, ViTs, and hybrid architectures, and provides a lower inference time (8.3 ms/image). On the more heterogeneous Dataset 2, the model maintains strong performance, with an accuracy of 97.0%, precision of 95.4%, recall of 94.8%, and F1-score of 95.1%, demonstrating its resilience to domain shift and imaging variability. These results underscore the value of structural multi-scale feature interaction and prototype-driven classification for robust mammographic analysis. The consistent performance across internal and external evaluations indicates the potential for the proposed framework to be reliably applied in computer-aided screening systems.