ArticleLife (Basel, Switzerland)2026
Age- and Severity-Stratified Associations Among Polysomnographic Parameters, Lower Urinary Tract Symptoms, and Hormonal Markers in Men with Obstructive Sleep Apnea: A Cross-Sectional Study.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObstructive sleep apnea (OSA) is associated with lower urinary tract symptoms (LUTS), particularly nocturia, though mechanisms including hypoxia, intrathoracic pressure changes, and hormonal alterations. While age and severity may influence these associations, stratified analyses remain limited. This study examined polysomnographic (PSG) parameters, International Prostate Symptom Score (IPSS) components, and hormonal/electrolyte markers in age- and severity-stratified men with suspected OSA.
methodsIn this cross-sectional study, 104 men (mean age 60.8 ± 9.8 years) underwent PSG. Analyses were stratified by age (<60 vs. ≥60 years) and respiratory disturbance index (RDI) severity. Correlations were used to assess PSG indices, IPSS subdomains (irritative, obstructive, quality of life [QoL]), and markers including antidiuretic hormone [ADH], aldosterone, plasma renin activity [PRA], sodium, potassium. Nocturnal polyuria index (NPI ≥ 33%) was calculated in a subset of participants. Pearson correlations, ANOVA, and Kruskal-Wallis tests were used (
resultsModerate OSA predominated (RDI 27.2 ± 20.4 events/h); nocturia affected 61.5% of the cohort. In those <60 years (
conclusionsAge and OSA severity modulate PSG-LUTS-hormonal associations. Younger men exhibit hypoxia-linked obstructive symptoms, whereas older men experience sleep fragmentation that impacts QoL. ADH suppression is associated with severe OSA.
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