Evidence map›Paper›PMID 41900894›Full record

ReviewLife (Basel, Switzerland)2026

Molecular Mechanistic Pathways Targeted by Natural Products in the Prevention and Treatment of Alcoholic Liver Disease.

Kaixuan Zhou, Jincai Li, Menghu Wang, Mingjun Yu, Jing Wang

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaixuan ZhouCollege of Traditional Chinese Medicine, Bozhou University, Bozhou 236800, China.ORCID 0000-0001-7621-0715
Jincai LiCollege of Traditional Chinese Medicine, Bozhou University, Bozhou 236800, China.
Menghu WangCollege of Traditional Chinese Medicine, Bozhou University, Bozhou 236800, China.ORCID 0009-0009-1322-3389
Mingjun YuCollege of Traditional Chinese Medicine, Bozhou University, Bozhou 236800, China.ORCID 0000-0003-1029-5538
Jing WangCollege of pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.

Funding

Bozhou Science and Technology Bureau Project bzzd2025002scientific project of Bozhou University BYKQ202521
6 · The paper itself

Abstract

Alcoholic liver disease (ALD) is a condition caused by alcohol abuse. Although its incidence is rapidly increasing, effective treatments for this disease remain limited. The pathogenesis of ALD involves multiple aspects, such as direct damage from alcohol, oxidative stress, inflammation, lipid metabolism disorders, and dysbiosis of the gut microbiota. Under the combined action of multiple damaging factors, liver inflammation worsens and leads to liver fibrosis. In this review, we focused on in vitro and in vivo experiments to investigate the mechanistic pathways by which natural products exert effects against the progression of ALD. The accumulated and collected data indicate that some natural products may regulate oxidative stress, inflammation, autophagy, lipid metabolism, and the intestinal barrier, thereby protecting the liver. This review presents an updated overview of the potential benefits of these natural products for the prevention and treatment of ALD, identifying potential new therapeutic lead compounds and providing a reference for innovative drug development and clinical treatment for ALD.

Indexed as

alcoholic liver diseaseinflammationlipid depositionmechanismnatural productsoxidative stress

Identifiers

PMID41900894
PMCPMC13027629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.