Evidence map›Paper›PMID 41900892›Full record

ArticleLife (Basel, Switzerland)2026

Metabolites from South African Medicinal Plants as Dual-Function Inhibitors of the SARS-CoV-2 Papain-like Protease (PL

Mmamudi Anna Makhafola, Clarissa Marcelle Naidoo, Chikwelu Lawrence Obi, Benson Chuks Iweriebor, Oyinlola Oluwunmi Olaokun, Earl Prinsloo, Haruhisa Kikuchi, Muhammad Sulaiman Zubair, Nqobile Monate Mkolo

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mmamudi Anna MakhafolaDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0009-0006-6080-1848
Clarissa Marcelle NaidooDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0001-9164-8213
Chikwelu Lawrence ObiDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Benson Chuks IwerieborDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Oyinlola Oluwunmi OlaokunDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0002-8004-3187
Earl PrinslooDepartment of Biotechnology, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-3048-4304
Haruhisa KikuchiFaculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.ORCID 0000-0001-6938-0185
Muhammad Sulaiman ZubairDepartment of Pharmacy, University of Tadulako, Palu 94118, Indonesia.
Nqobile Monate MkoloDepartment of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0003-3631-4522

Funding

South African Medical Research Council SAMRC RCDI-Nested PhD Scholarship Programme, 2025/26
6 · The paper itself

Abstract

The SARS-CoV-2 papain-like protease (PL

Indexed as

Acorus calamuscatechin-7-glucosideenzyme inhibitionLippia javanicametabolomicsmolecular dockingS-adenosyl-methionineSARS-CoV-2 PLpro

Identifiers

PMID41900892
PMCPMC13028120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.