ReviewPharmaceutics2026
Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems.
Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Computational screening of natural deep eutectic solvents for improving naringenin solubilization and membrane behavior in DMPC liposomes Using COSMO-RS and COSMOmic.Journal of molecular modeling · 2026Article
- Article
- Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives.Marine drugs · 2026Review
- A Review on Recent Progress and Clinical Translation of Self-Assembled Hydrogels in Diabetic Wound Repair.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The human skin, specifically the stratum corneum (SC), remains a formidable barrier to the delivery of therapeutic agents. Nearly 80% of new drug candidates exhibit poor solubility or low permeability, necessitating the development of novel delivery vehicles. Therapeutic deep eutectic solvents (TheDES) have emerged as a "green," multifunctional solution capable of significantly enhancing the solubility and transdermal flux of active pharmaceutical ingredients (APIs). This review discusses the physicochemical fundamentals of TheDES, mechanisms of permeation enhancement-including the newly identified "lipid exchange" effect-and the transition from liquid solvents to advanced dosage forms such as eutectogels and nanoemulsions. Current therapeutic applications in pain management, infectious diseases, and chronic conditions are highlighted, alongside critical assessments of dermatological safety and future directions in computational modeling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.