Evidence map›Paper›PMID 41900774›Full record

ArticlePharmaceutics2026

Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo.

Yuying Ma, Yang Teng, Jinjin Liu, Yuke Deng, Lingbo Xu, Ruichen Gao, Tingyu Peng, Wei Li, Yue Wei, Linfeng Li and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuying MaCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0003-4218-9297
Yang TengCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Jinjin LiuCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yuke DengCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Lingbo XuCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Ruichen GaoCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Tingyu PengCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Wei LiDepartment of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yue WeiCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-1673-2826
Linfeng LiCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0001-6185-4999
Zufeng GuoCollege of Pharmacy, Chongqing Medical University, Chongqing 400016, China.

Funding

China Postdoctoral Science Foundation 2022M720612CQMU Program for Youth Innovation in Future Medicine W0074Entrepreneurship and Innovation Support Plan of Chongqing for Returned Overseas Scholars 2305013383486448Entrepreneurship and Innovation Support Plan of Chongqing for Returned Overseas Scholars 2508013605744353National Natural Science Foundation of China 22207014National Natural Science Foundation of China 22277010National Natural Science Foundation of China 22307013National Natural Science Foundation of China 22477013National Natural Science Foundation of China 32200075National Natural Science Foundation of China 92353393Natural Science Foundation of Chongqing, China CSTB2022NSCQ-BHX0667Natural Science Foundation of Chongqing, China CSTB2022NSCQ-MSX1061Natural Science Foundation of Chongqing, China CSTB2023NSCQ-MSX0740Science and Technology Research Program of Chongqing Municipal Education Commission KJQN202300456
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antitumor efficacyPIN1proteolysis-targeting chimerasstructure–activity relationship

Identifiers

PMID41900774
PMCPMC13029591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.