Evidence map›Paper›PMID 41900767›Full record

ArticlePharmaceutics2026

Liposomal CRISPR/Cas9-Mediated Local Genome Editing for Joint Disease in Mucopolysaccharidosis Type I.

Hallana Souza Santos, Edina Poletto, Luisa Natalia Pimentel Vera, Mirian Farinon, Francyne Kubaski, Paola Barcelos Carneiro, Willian da Silva Carniel, Roberto Giugliani, Ursula Matte, Helder Ferreira Teixeira and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hallana Souza SantosLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.
Edina PolettoLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-0554-0295
Luisa Natalia Pimentel VeraLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.
Mirian FarinonPrograma de Pós-Graduação em Ciências Médicas da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Medicina, Campus Saúde, Av. Ramiro Barcelos, 2400, Porto Alegre 90035-003, RS, Brazil.
Francyne KubaskiPrograma de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, RS, Brazil.ORCID 0000-0002-9330-0154
Paola Barcelos CarneiroLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0001-8401-3332
Willian da Silva CarnielPrograma de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil.ORCID 0009-0001-2820-2814
Roberto GiuglianiPrograma de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, RS, Brazil.ORCID 0000-0001-9655-3686
Ursula MatteLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-4977-6662
Helder Ferreira TeixeiraPrograma de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil.
Roselena Silvestri SchuhLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-4189-0436
Guilherme BaldoLaboratório Células, Tecidos e Genes do Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-1598-5861

Funding

Financiamento e Incentivo à Pesquisa of Hospital de Clínicas de Porto Alegre FIPE/HCPA 2019-0122National Council for Scientific and Technological Development (CNPq) 470888/2014-8 and 141742/2014-3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR/Cas9gene therapyintra-articularliposomemicrofluidicsmucopolysaccharidosis type Inonviral vector

Identifiers

PMID41900767
PMCPMC13029379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.