Evidence map›Paper›PMID 41900334›Full record

ArticleMicroorganisms2026

Design, Synthesis, and Anti-Biofilm Activity of C-28 Modified Betulinic Acid Derivatives Targeting SarA in Drug-Resistant

Dongshun Jia, Junchao Zhang, Xuejin Zhang, Peng Gao, Hongyu Zhan, Zihan Dong, Hao Li, Fanhao Meng, Nan Cai, Dajun Zhang

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dongshun JiaSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Junchao ZhangSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Xuejin ZhangSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Peng GaoFaculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-6877-6388
Hongyu ZhanFaculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
Zihan DongSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Hao LiSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Fanhao MengSchool of Pharmacy, China Medical University, Shenyang 110034, China.ORCID 0000-0002-1331-2164
Nan CaiSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.ORCID 0000-0002-6696-0966
Dajun ZhangSchool of Pharmacy, Shenyang Medical College, Shenyang 110034, China.

Funding

the Natural Science Foundation of Liaoning Province 2025-BS-0858the Project of the Science and Technology Department of Liaoning Province 2024-MS-226
6 · The paper itself

Abstract

To address the urgent challenge of antimicrobial resistance, a series of twenty novel C-28 modified betulinic acid derivatives was designed and synthesized. Several derivatives, particularly

Indexed as

antibacterial activitybetulinic acidbiofilm inhibitionmolecular docking

Identifiers

PMID41900334
PMCPMC13029524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.