Evidence map›Paper›PMID 41900330›Full record

ReviewMicroorganisms2026

Review in Structure-Activity Relationships, Synthetic Regulation, and Applications of Mono/Di-Rhamnolipids.

Zhen Li, Liuyu Gao, Shengze Su, Rui Wang, Peng Lei, Yian Gu, Yongting Song, Hong Xu, Liang Sun

Abstract readReview
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhen LiCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Liuyu GaoCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Shengze SuCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Rui WangCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Peng LeiCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.ORCID 0000-0001-5538-3780
Yian GuCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Yongting SongResearch Institute of Petroleum Engineering and Technology, Sinopec Shengli Oilfield, Dongying 257000, China.
Hong XuCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Liang SunCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.

Funding

Jiangsu Basic Research Center for Synthetic Biology BK20233003National Key Research and Development Program of China 2022YFC2105200
6 · The paper itself

Abstract

Rhamnolipids (RLs) are natural biosurfactants produced by microbial fermentation. They exhibit excellent surface activity, environmental compatibility, and versatile biological activities, with broad application potential in energy development, environmental remediation, personal care, and biomedicine. In recent years, RLs have garnered significant attention due to the structural divergence between mono-rhamnolipids (mono-RLs) and di-rhamnolipids (di-RLs). Their distinct physicochemical and biological properties necessitate structure-function-guided "tailor-made" synthesis. Notably, the compositional fluctuation of naturally occurring RL mixtures constrains their high-value utilization. This review systematically summarizes the structure-function relationships, microbial biosynthetic pathways, and regulatory approaches of mono-RLs and di-RLs, with a core focus on the targeted production of RLs with specific mono-/di-RL ratios. The review also highlights the application-specific suitability of the two RL congeners. It aims to provide a theoretical foundation and technical reference for the precision manufacturing and commercialization of RLs in energy, environment, health, and other related fields.

Indexed as

bioactivitybiosurfactantsmono/di-rhamnolipidssurface activity

Identifiers

PMID41900330
PMCPMC13029309

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.