Evidence map›Paper›PMID 41900304›Full record

ArticleMicroorganisms2026

Anti-β2GPI/HLA-DR Antibody, Chronic Endometritis, and Uterine Endometrial Microbiome in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study.

Hideto Yamada, Yosuke Ono, Hajime Ota, Yuta Kobayashi, Yoshiyuki Fukushi, Shinichiro Wada, Hisashi Arase

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hideto YamadaCenter for Recurrent Pregnancy Loss, Teine Keijinkai Hospital, 1-40, 12-Chome, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan.ORCID 0000-0001-9839-2214
Yosuke OnoDepartment of Obstetrics and Gynecology, University of Yamanashi, 1110 Shimokato, Chuo 409-3898, Yamanashi, Japan.
Hajime OtaDepartment of Obstetrics and Gynecology, Teine Keijinkai Hospital, 1-40, 12-Chome, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan.ORCID 0000-0003-1764-8172
Yuta KobayashiDepartment of Obstetrics and Gynecology, Teine Keijinkai Hospital, 1-40, 12-Chome, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan.
Yoshiyuki FukushiDepartment of Obstetrics and Gynecology, Teine Keijinkai Hospital, 1-40, 12-Chome, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan.
Shinichiro WadaDepartment of Obstetrics and Gynecology, Teine Keijinkai Hospital, 1-40, 12-Chome, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan.ORCID 0000-0002-3593-4415
Hisashi AraseLaboratory of Immunochemistry, World Premier International Immunology Frontier Research Center, Suita 565-0871, Osaka, Japan.

Funding

Japan Agency for Medical Research and Development JP21gk0110047, JP22gk0110061, JP23fk0108682, and JP25gn0110094Japan Society for the Promotion of Science 20K09642, 23K08888, and 24K02691
6 · The paper itself

Abstract

Anti-β2GPI/HLA-DR antibody, chronic endometritis (CE), and endometrial dysbiosis are likely to be associated with the etiologies of recurrent pregnancy loss (RPL). This prospective cohort study aimed to investigate these new risk factors together with conventional causes for RPL, and to evaluate pregnancy outcomes in women individually treated. A total of 87 women with RPL underwent conventional assessment together with anti-β2GPI/HLA-DR antibody measurements, CD138 immunohistochemistry for CE, and 16S rRNA sequence analysis for endometrial microbiome. Women with anti-β2GPI/HLA-DR antibody, CE, and endometrial dysbiosis received low-dose aspirin and heparin, antibiotics, and probiotics, respectively. Pregnancy outcomes of the participants were assessed. Anti-β2GPI/HLA-DR antibody, CE, non-

Indexed as

chronic endometritisendometrial microbiomeHLA-DRrecurrent pregnancy lossβ2-glycoprotein I

Identifiers

PMID41900304
PMCPMC13029616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.