Evidence map›Paper›PMID 41900143›Full record

ArticleMolecules (Basel, Switzerland)2026

The Difluoroboranyl-Fluoroquinolone Derivative "7a" Inhibits Bacterial DNA Gyrase and Exhibits Potent Activity Against Ciprofloxacin-Resistant

Luis Angel Veyna-Hurtado, Hiram Hernández-López, Denisse de Loera, Juan Manuel Vargas-Morales, Martín Muñoz-Ortega, Lorena Troncoso-Vázquez, Alondra Bocanegra-Zapata, Alberto Rafael Cervantes-Villagrana

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luis Angel Veyna-HurtadoFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.ORCID 0000-0003-0002-4419
Hiram Hernández-LópezLaboratorio de Investigación en Síntesis Orgánica y Modificación Química, Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0002-4286-163X
Denisse de LoeraFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.ORCID 0000-0002-5291-2197
Juan Manuel Vargas-MoralesLaboratorio de Análisis Clínicos, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78100, Mexico.
Martín Muñoz-OrtegaLaboratorio de Patología Molecular, Departamento de Química, Universidad Autónoma de Aguascalientes, Aguascalientes 20100, Mexico.ORCID 0000-0002-1961-6919
Lorena Troncoso-VázquezDepartamento de Patología, Instituto Mexicano del Seguro Social (IMSS), Zacatecas 99000, Mexico.
Alondra Bocanegra-ZapataFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.
Alberto Rafael Cervantes-VillagranaLaboratorio de Investigación en Terapéutica Experimental, Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0001-7344-353X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to the World Health Organization, antibiotic research remains insufficient, emphasizing the urgent need for new active molecules, particularly against resistant bacteria. Based on known antibacterial scaffolds, new fluoroquinolone derivatives have been synthesized by our research group, including compound

methodsThe minimum inhibitory (MIC) and bactericidal (MBC) concentrations of compound

resultsCompound

conclusionsCompound

Indexed as

Anti-Bacterial AgentsCiprofloxacinDNA GyraseDrug Resistance, BacterialFluoroquinolonesStaphylococcus aureusTopoisomerase II InhibitorsAnimalsDisease Models, AnimalEscherichia coliMiceMice, Inbred BALB CMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsCiprofloxacinDNA GyraseFluoroquinolonesTopoisomerase II Inhibitorsfluoroquinolonehistopathologymolecular dockingpneumoniaresistanceS. aureustoxicity

Identifiers

PMID41900143
PMCPMC13029244

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.