Acridinium Chemiluminogenic Labels-Synthesis, Analytical Performance, and Mechanism of Light Generation-A Comparison in View of Biomedical Diagnostics.

Karol Krzymiński, Beata Zadykowicz, Justyna Czechowska, Paweł Rudnicki-Velasquez, Illia Serdiuk, Adam K Sieradzan, Lucyna Holec-Gąsior

Abstract readComparative Study

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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Karol KrzymińskiFaculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.

Beata ZadykowiczFaculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.ORCID 0000-0002-7125-5233

Justyna CzechowskaCyprotex Discovery Ltd., No. 24 Mereside, Alderley Park, Nether Alderley, Cheshire SK10 4TG, UK.

Paweł Rudnicki-VelasquezDepartment of Falsified Medicines and Medical Devices, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland.ORCID 0000-0003-0368-0112

Illia SerdiukFaculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.ORCID 0000-0002-4563-0773

Adam K SieradzanFaculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.ORCID 0000-0002-2426-3644

Lucyna Holec-GąsiorDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12 Str., 80-233 Gdańsk, Poland.ORCID 0000-0001-5421-6905

Funding

National Science Centre 2011/03/D/ST4/02419

6 · The paper itself

Abstract

This paper presents the synthesis, physicochemical characterisation, and analytical applications of chemiluminescent (CL) labels based on acridinium salts (ALs) for biomedical diagnostics. These compounds emit light as a result of oxidative reactions and represent an established class of reagents widely employed in chemiluminescence immunochemical assays (CLIAs) today. A series of structurally differentiated acridinium labels (

Indexed as

AcridinesLuminescent MeasurementsHumansImmunoassayImmunoglobulin GLuminescenceSurface-Active AgentsAcridinesImmunoglobulin GSurface-Active Agentsacridinium chemiluminescenceDFT calculationimmunodiagnosticslabellingsemi-empirical approachstatisticssurfactants

Identifiers

PMID41900140

DOI10.3390/molecules31061041

PMCPMC13029182

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