ArticleMolecules (Basel, Switzerland)2026
Mechanistic Insights into Quorum Quenching-Mediated Control of EPS and Biofilm Formation in Submerged MBR.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Quorum-quenching enzymes as next-generation antibiofilm therapeutics: mechanisms, applications, and future perspectives.World journal of microbiology & biotechnology · 2026Review
- Enhanced Durability of Cellulose-Reinforced PVA-SA Beads for Long-Term Quorum Quenching Applications in Membrane Bioreactors.Gels (Basel, Switzerland) · 2026Article
- Comparative Evaluation of QQ Media Materials for MBR Applications: An Environmental Footprint Approach in Urban Wastewater Treatment Plants.Membranes · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum quenching (QQ) is a promising biological approach that has the potential to control membrane biofouling. However, the implementation of the QQ membrane bioreactor still requires a more systematic and comprehensive understanding, including the selection of membrane materials, the determination of the optimal QQ bacterial dosage, and the use of appropriate media for the immobilization of QQ bacteria, all of which are important to ensure long-term operation. The present study investigated the impact of QQ bacteria on biofilm formation across different polymeric membranes. These include flat sheet membranes, Polytetrafluoroethylene (PTFE), Polysulfones (PSs), and hollow-fibre polyvinylidene difluoride (PVDF) membranes. It also evaluated biofilm development, membrane filtration performance, extracellular polymeric substance (EPS) production, and sludge floc properties, which were characterized using fluorescence microscopy. The results revealed that QQ intervention markedly suppressed quorum sensing (QS), leading to a pronounced, dose-dependent reduction in biofilm thickness, membrane fouling, EPS production and sludge floc size. Biofilm thickness was reduced by 63.5% on PTFE and 55.4% on PS membranes, accompanied by a notable reduction in EPS protein and polysaccharides, thereby weakening the biofilm formation and enhancing membrane filterability. Therefore, the permeability performance of the PVDF membrane improved by 338.2%. Furthermore, sludge settleability was enhanced, and floc size was reduced, resulting in the mitigation of biofilm formation without impacting pollutant degradation. These findings elucidate the material-dependent and dose-responsive mechanism by which QQ regulates EPS synthesis and biofilm formation in MBR.
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