Evidence map›Paper›PMID 41900025›Full record

ReviewMolecules (Basel, Switzerland)2026

Synthetic Strategies and Biological Diversity of Biflavonoids: Current Status and Perspective.

Yu Zhang, Yue Chai, Jiabin Wu, Shuyu Wang, Jinxin Shi, Minzhen Wei, Runhui Liu, Chunlin Zhuang

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Patterns of Biflavonoid Accumulation in Ginkgo (Plants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu ZhangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.ORCID 0009-0000-7719-4868
Yue ChaiThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Jiabin WuThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Shuyu WangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Jinxin ShiThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Minzhen WeiSchool of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
Runhui LiuThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Chunlin ZhuangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.ORCID 0000-0002-0569-5708

Funding

National Natural Science Foundation of China 82574241
6 · The paper itself

Abstract

Biflavonoids are natural or pseudo-natural polyphenolic compounds formed by linking two flavonoid monomers via different bonds. Their unique dimeric structure endows them with broad-spectrum biological activities, establishing them as a core focus in drug development. However, the extremely low abundance and high structural similarity of natural biflavonoids present significant challenges. Consequently, synthetic technology has become a solution to overcome bottlenecks in supplements. The approaches involving chemical synthesis, emerging synthetic strategies, and biosynthesis are employed for the synthesis of different biflavonoids. In this review, we systematically summarize the application of diverse synthetic methods and clarify the extensive biological activities of the biflavonoids. Furthermore, we discuss the current challenges in biflavonoid synthesis and biological applications, as well as providing an outlook on future directions.

Indexed as

BiflavonoidsChemistry Techniques, SyntheticAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsHumansMolecular StructureAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsBiflavonoidsanticanceranti-inflammationantimicrobial activitybiflavonoidsbiosynthesischemical synthesisgreen synthesissynthetic strategies

Identifiers

PMID41900025
PMCPMC13028642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.