Evidence map›Paper›PMID 41900018›Full record

ArticleMolecules (Basel, Switzerland)2026

Discovery of a Novel Coumarin/Thiazole Chalcone Hybrid as a Potent Dual Inhibitor of Tubulin and Carbonic Anhydrases IX & XII with Promising Anti-Proliferative Activity.

Basima A A Saleem, Ashraf A Qurtam, Mohamed Ahmed, Raed Fanoukh Aboqader Al-Aouadi, Ali Abdulrazzaq Abdulhussein Alrikabi, Helal F Hetta, Stefan Bräse, Ghallab Alotaibi, Abdullah Alkhammash, Sara Mahmoud Farhan

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Basima A A SaleemDepartment of Chemistry, College of Science, University of Mosul, Mosul 41001, Iraq.ORCID 0000-0002-5947-701X
Ashraf A QurtamBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.ORCID 0000-0002-7627-6105
Mohamed AhmedCollege of Medicine, Dhofar University, Salalah 122, Oman.ORCID 0000-0003-1943-8419
Raed Fanoukh Aboqader Al-AouadiCollege of Medicine, Al-Ayen Iraqi University (AUIQ), An Nasiriyah 64001, Iraq.ORCID 0009-0000-7543-4020
Ali Abdulrazzaq Abdulhussein AlrikabiCollege of Medicine, University of Thi-Qar, Nasiriyah 64001, Iraq.
Helal F HettaDivision of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-2810-8246
Stefan BräseInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Ghallab AlotaibiDepartment of Pharmacology, College of Pharmacy, Al-Dawadmi Campus, Shaqra University, Shaqra 11961, Saudi Arabia.
Abdullah AlkhammashDepartment of Pharmacology, College of Pharmacy, Al-Dawadmi Campus, Shaqra University, Shaqra 11961, Saudi Arabia.ORCID 0009-0002-2000-2620
Sara Mahmoud FarhanDepartment of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, New Minia 61768, Egypt.ORCID 0000-0002-7857-2020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multitarget-directed ligands offer a promising strategy for overcoming tumor complexity through simultaneous modulation of complementary oncogenic pathways. In this work, a novel (

Indexed as

Antineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesChalconeCoumarinsThiazolesTubulin ModulatorsAntigens, NeoplasmApoptosisCell Line, TumorCell ProliferationDrug DiscoveryHumansMolecular Docking SimulationStructure-Activity RelationshipAntigens, NeoplasmAntineoplastic AgentsCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIIChalconeCoumarinsThiazolesTubulinTubulin Modulatorsapoptosiscarbonic anhydrasecoumarinsthiazole chalconestubulin

Identifiers

PMID41900018
PMCPMC13028722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.